PMID- 17485542
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20220311
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 88
IP  - Pt 6
DP  - 2007 Jun
TI  - Search for DNA of exogenous mouse mammary tumor virus-related virus in human 
      breast cancer samples.
PG  - 1806-1809
LID - 10.1099/vir.0.82767-0 [doi]
AB  - Earlier reports of a human exogenous retrovirus (HMTV) related closely to mouse 
      mammary tumor virus (MMTV) led us to search for these viral sequences in breast 
      cancer tissues and normal tissues. A real-time PCR was developed based on MMTV 
      and published HMTV envelope sequences. The real-time PCR method can detect one to 
      ten copies of MMTV target DNA. Tissue samples were collected prospectively from 
      18 breast cancer patients and 11 non-malignant control cases, as well as 
      peripheral blood leukocytes from the same women. Despite the high sensitivity of 
      the real-time PCR method used, none of the samples were positive for HMTV DNA or 
      RNA. The absence of HMTV DNA in both breast cancer samples and controls indicates 
      either that the concentration of putative HMTV DNA in the breast cancers was too 
      low for detection or that it did not exist there.
FAU - Bindra, A
AU  - Bindra A
AD  - Section of Virology, Department of Medical Sciences, Uppsala University Hospital, 
      Uppsala, Sweden.
FAU - Muradrasoli, S
AU  - Muradrasoli S
AD  - Section of Virology, Department of Medical Sciences, Uppsala University Hospital, 
      Uppsala, Sweden.
FAU - Kisekka, R
AU  - Kisekka R
AD  - Section of Virology, Department of Medical Sciences, Uppsala University Hospital, 
      Uppsala, Sweden.
FAU - Nordgren, H
AU  - Nordgren H
AD  - Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden.
FAU - Warnberg, F
AU  - Warnberg F
AD  - Department of Surgery, Uppsala University Hospital, Uppsala, Sweden.
FAU - Blomberg, J
AU  - Blomberg J
AD  - Section of Virology, Department of Medical Sciences, Uppsala University Hospital, 
      Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Base Sequence
MH  - Betaretrovirus/genetics/*isolation & purification
MH  - Breast Neoplasms/*virology
MH  - DNA, Viral/*analysis/genetics
MH  - Female
MH  - Humans
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction/methods
MH  - Prospective Studies
MH  - Sequence Alignment
EDAT- 2007/05/09 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/05/09 09:00
PHST- 2007/05/09 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/05/09 09:00 [entrez]
AID - 10.1099/vir.0.82767-0 [doi]
PST - ppublish
SO  - J Gen Virol. 2007 Jun;88(Pt 6):1806-1809. doi: 10.1099/vir.0.82767-0.