PMID- 1748677
OWN - NLM
STAT- MEDLINE
DCOM- 19920117
LR  - 20210210
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 266
IP  - 35
DP  - 1991 Dec 15
TI  - Glucose increases the expression of the ATP/ADP translocator and the 
      glyceraldehyde-3-phosphate dehydrogenase genes in Chlorella.
PG  - 24044-7
AB  - A presumably full-length cDNA clone of the mitochondrial ATP/ADP translocator 
      (AAT) of Chlorella kessleri has been isolated and sequenced. The expression of 
      the AAT gene is highly increased in the presence of D-glucose (14 mM). At least 
      nine more genes are activated when autotrophically grown Chlorella cells switch 
      to heterotrophic growth. Among these is the HUP1 gene coding for the hexose 
      transporter (Sauer, N., Caspari, T., Klebl, F., and Tanner, W. (1990) Proc. Natl. 
      Acad. Sci. U.S.A. 87, 7949-7952) and, as also shown in this paper, the 
      glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene. When glucose or the 
      nonmetabolizable analogue 6-deoxyglucose is added to the cells, an increased 
      expression of GAPDH or AAT is observed after 10 or 30 min, respectively. Hexose 
      uptake mutants (HUP1-) do not respond to sugars in this way, which indicates that 
      either the inducer has to be internalized or that the HUP1 translocator is part 
      of the signal transduction mechanism.
FAU - Hilgarth, C
AU  - Hilgarth C
AD  - Lehrstuhl fur Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, 
      Germany.
FAU - Sauer, N
AU  - Sauer N
FAU - Tanner, W
AU  - Tanner W
LA  - eng
SI  - GENBANK/M55199
SI  - GENBANK/M55200
SI  - GENBANK/M55201
SI  - GENBANK/M76669
SI  - GENBANK/M96682
SI  - GENBANK/S66610
SI  - GENBANK/S66768
SI  - GENBANK/S70234
SI  - GENBANK/S70236
SI  - GENBANK/S70327
SI  - GENBANK/S70686
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 9007-49-2 (DNA)
RN  - 9068-80-8 (Mitochondrial ADP, ATP Translocases)
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cattle
MH  - Chlorella/drug effects/enzymology/*genetics
MH  - DNA/genetics/isolation & purification
MH  - Glucose/*pharmacology
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/*genetics
MH  - Mitochondria/enzymology
MH  - Mitochondrial ADP, ATP Translocases/*genetics
MH  - Molecular Sequence Data
MH  - Saccharomyces cerevisiae/enzymology/genetics
MH  - Sequence Homology, Nucleic Acid
EDAT- 1991/12/15 00:00
MHDA- 1991/12/15 00:01
CRDT- 1991/12/15 00:00
PHST- 1991/12/15 00:00 [pubmed]
PHST- 1991/12/15 00:01 [medline]
PHST- 1991/12/15 00:00 [entrez]
AID - S0021-9258(18)54389-1 [pii]
PST - ppublish
SO  - J Biol Chem. 1991 Dec 15;266(35):24044-7.