PMID- 17487448
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20211203
IS  - 0770-3198 (Print)
IS  - 0770-3198 (Linking)
VI  - 27
IP  - 1
DP  - 2008 Jan
TI  - HLA class 1 associations in Henoch Schonlein purpura: increased and decreased 
      frequencies.
PG  - 5-10
AB  - Henoch Schonlein purpura (HSP) is the most common vasculitis of childhood. 
      Susceptibility to HSP and associated clinical heterogeneity in HSP may be 
      conferred by a number of genetic loci, including the major histocompatibility 
      complex. We aimed to investigate the implications of the human leukocyte antigen 
      (HLA) class 1 alleles in susceptibility to HSP and determine the possible 
      associations with renal, gastrointestinal (GI), and joint manifestations of the 
      disease. 110 children with HSP (66 boys, 44 girls) and 250 unrelated healthy 
      controls were enrolled in the study. The mean age was 8.65 +/- 3.59 years. HSP 
      was diagnosed on the basis of clinical and laboratory data according to the 
      American College of Rheumatology classification. The diagnosis was supported with 
      skin and/or kidney in most of the patients. Clinical and laboratory findings 
      revealed: skin involvement in 110 (100%), joint manifestations in 82 (74.5%), GI 
      symptoms in 58 (52.7%), and hematuria and/or proteinuria in 36 (32.7%) patients. 
      HLA class 1 alleles were identified by DNA amplification, hybridized with 
      specific primer sequences. Comparison of frequencies between patients and 
      controls were made by using the Fisher's exact test. Odds ratio (OR) was used as 
      the measure of association. HLA A2, A11, and B35 antigens showed an increased 
      risk for predisposition to HSP (OR = 1.714, 95%CI = 1.088-2.700, p = 0.020; OR = 
      2.185, 95%CI = 1.289-3.703, p = 0.003; and OR = 2.292, 95%CI = 1.451-3.619, p = 
      0.000, respectively), while HLA A1, B49, and B50 antigens revealed decreased risk 
      for predisposition to HSP (OR = 4.739, 95%CI = 1.828-12.345, p = 0.001; OR = 
      3.268, 95%CI = 0.955-11.236, p = 0.047; and OR = 7.462, 95%CI = 0.975-55.555, p = 
      0.024, respectively). Considering the renal involvement and severity of 
      proteinuria, there was no association with HLA class 1 alleles. Our results 
      suggest that the increased frequency of HLA A2, A11, and B35 alleles in 
      unselected pediatric HSP patient population and miscarrying of HLA A1, B49, and 
      B50 could be considered as a risk factor for susceptibility to HSP.
FAU - Peru, Harun
AU  - Peru H
AD  - Department of Pediatric Nephrology, Gazi University Hospital, Besevler, Ankara, 
      Turkey, 06540. peruharun@yahoo.com
FAU - Soylemezoglu, Oguz
AU  - Soylemezoglu O
FAU - Gonen, Sevim
AU  - Gonen S
FAU - Cetinyurek, Aysun
AU  - Cetinyurek A
FAU - Bakkaloglu, Sevcan Azime
AU  - Bakkaloglu SA
FAU - Buyan, Necla
AU  - Buyan N
FAU - Hasanoglu, Enver
AU  - Hasanoglu E
LA  - eng
PT  - Journal Article
DEP - 20070509
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gastrointestinal Diseases/etiology/genetics/immunology
MH  - *Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genetic Predisposition to Disease
MH  - HLA-B Antigens/blood/genetics
MH  - Histocompatibility Antigens Class I/blood/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - IgA Vasculitis/complications/*genetics/immunology
MH  - Joint Diseases/etiology/genetics/immunology
MH  - Kidney Diseases/etiology/genetics/immunology
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Proteinuria/etiology/genetics/immunology
EDAT- 2007/05/10 09:00
MHDA- 2008/02/06 09:00
CRDT- 2007/05/10 09:00
PHST- 2007/02/11 00:00 [received]
PHST- 2007/04/17 00:00 [accepted]
PHST- 2007/04/16 00:00 [revised]
PHST- 2007/05/10 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/05/10 09:00 [entrez]
AID - 10.1007/s10067-007-0640-z [doi]
PST - ppublish
SO  - Clin Rheumatol. 2008 Jan;27(1):5-10. doi: 10.1007/s10067-007-0640-z. Epub 2007 
      May 9.