PMID- 17488668
OWN - NLM
STAT- MEDLINE
DCOM- 20070809
LR  - 20191210
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Linking)
VI  - 92
IP  - 4
DP  - 2007 Apr
TI  - Lack of correlation between heparin dose and standard clinical monitoring tests 
      in treatment with unfractionated heparin in critically ill children.
PG  - 554-7
AB  - The activated partial thromboplastin time (aPTT) and anti-Xa activity are used 
      for monitoring unfractionated heparin (UFH) therapy in children and may not be 
      optimal. OBJECTIVE: Determine correlations of aPTT, anti-Xa and UFH dose in 
      children. Single centre prospective cohort study in children receiving UFH. The 
      aPTT and anti-Xa results from routine coagulation monitoring were collected. 
      Thirty-nine children (median age 18 days) were enrolled. There was no 
      relationship between aPTT and UFH dose (r2=0.12) or anti-Xa and UFH dose 
      (r2=0.03) or aPTT and anti-Xa (r2=0.22). aPTT and anti-Xa do not accurately 
      monitor UFH therapy in children.
FAU - Kuhle, Stefan
AU  - Kuhle S
AD  - Division of Haematology/Oncology, Department of Population Health Sciences, The 
      Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
FAU - Eulmesekian, Pablo
AU  - Eulmesekian P
FAU - Kavanagh, Brian
AU  - Kavanagh B
FAU - Massicotte, Patricia
AU  - Massicotte P
FAU - Vegh, Patsy
AU  - Vegh P
FAU - Lau, Alice
AU  - Lau A
FAU - Mitchell, Lesley G
AU  - Mitchell LG
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (Anticoagulants)
RN  - 0 (Factor Xa Inhibitors)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Adolescent
MH  - Anticoagulants/*administration & dosage/adverse effects/pharmacology/therapeutic 
      use
MH  - *Blood Coagulation Tests
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Critical Care/*methods
MH  - Dose-Response Relationship, Drug
MH  - Drug Monitoring
MH  - *Factor Xa Inhibitors
MH  - Female
MH  - Heart Defects, Congenital/blood
MH  - Hemorrhage/chemically induced
MH  - Heparin/*administration & dosage/adverse effects/pharmacology/therapeutic use
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Partial Thromboplastin Time
MH  - Postoperative Complications/prevention & control
MH  - Prospective Studies
MH  - Pulmonary Embolism/drug therapy
MH  - Thrombin
MH  - Thrombophilia/drug therapy
MH  - Thrombosis/prevention & control
MH  - Venous Thrombosis/drug therapy
EDAT- 2007/05/10 09:00
MHDA- 2007/08/10 09:00
CRDT- 2007/05/10 09:00
PHST- 2007/05/10 09:00 [pubmed]
PHST- 2007/08/10 09:00 [medline]
PHST- 2007/05/10 09:00 [entrez]
AID - 10.3324/haematol.10696 [doi]
PST - ppublish
SO  - Haematologica. 2007 Apr;92(4):554-7. doi: 10.3324/haematol.10696.