PMID- 17488785
OWN - NLM
STAT- MEDLINE
DCOM- 20080107
LR  - 20220129
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 79
IP  - 1
DP  - 2008 Jan
TI  - Differences between intracranial vascular malformation types in the 
      characteristics of their presenting haemorrhages: prospective, population-based 
      study.
PG  - 47-51
AB  - OBJECTIVE: To determine the imaging and demographic characteristics of 
      intracranial haemorrhages, which are subsequently found to be due to an 
      underlying intracranial vascular malformation (IVM). METHODS: We compared the 
      demographic and brain imaging characteristics of adults presenting with 
      intracranial haemorrhage, subsequently found to be due to a brain arteriovenous 
      malformation (BAVM), dural arteriovenous fistula (DAVF) or cavernous malformation 
      (CM) in a prospective, population-based cohort of adults diagnosed for the first 
      time with an IVM (The Scottish IVM Study (SIVMS)). RESULTS: Of the 141 adults in 
      SIVMS who presented with intracranial haemorrhage, those with CMs presented at a 
      younger age and were less handicapped. A total of 115 (82%) had intracerebral 
      haemorrhage (ICH) with or without subarachnoid, intraventricular or subdural 
      extension. ICH without extension into other compartments accounted for all CM 
      bleeds, but only 50% of BAVM and DAVF bleeds. Median haematoma volumes differed 
      (Kruskal-Wallis, p<0.0001): ICH due to BAVM (16.0 cm3, inter-quartile range (IQR) 
      4.7 to 42.0) and DAVF (14.1 cm3, IQR 4.9 to 21.5) were similar, but CM haematoma 
      volumes were smaller (median 1.8 cm3, IQR 1.3 to 4.3). These findings were robust 
      in sensitivity analyses. Small haematoma volumes occurred among all IVM types; 
      the largest haematoma volume due to CM was 12 cm3, and volumes of >34 cm3 were 
      only due to BAVM. CONCLUSIONS: Intracranial haemorrhages found to be due to IVMs 
      differ in adults' age of presentation and clinical severity, as well as the 
      volume and distribution of the haematoma within the brain compartments.
FAU - Cordonnier, C
AU  - Cordonnier C
AD  - Division of Clinical Neurosciences, University of Edinburgh, Western General 
      Hospital, Edinburgh EH4 2XU, UK. Rustam.Al-Shahi@ed.ac.uk
FAU - Al-Shahi Salman, R
AU  - Al-Shahi Salman R
FAU - Bhattacharya, J J
AU  - Bhattacharya JJ
FAU - Counsell, C E
AU  - Counsell CE
FAU - Papanastassiou, V
AU  - Papanastassiou V
FAU - Ritchie, V
AU  - Ritchie V
FAU - Roberts, R C
AU  - Roberts RC
FAU - Sellar, R J
AU  - Sellar RJ
FAU - Warlow, C
AU  - Warlow C
CN  - SIVMS Collaborators
LA  - eng
GR  - CZG/2/265/CSO_/Chief Scientist Office/United Kingdom
GR  - G108/613/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070508
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arterio-Arterial Fistula/diagnosis
MH  - Diagnosis, Differential
MH  - Dura Mater/pathology
MH  - Female
MH  - Humans
MH  - Intracranial Arteriovenous Malformations/*diagnosis
MH  - Magnetic Resonance Angiography
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance/*methods
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Subarachnoid Hemorrhage/*diagnosis
MH  - Tomography, X-Ray Computed
EDAT- 2007/05/10 09:00
MHDA- 2008/01/08 09:00
CRDT- 2007/05/10 09:00
PHST- 2007/05/10 09:00 [pubmed]
PHST- 2008/01/08 09:00 [medline]
PHST- 2007/05/10 09:00 [entrez]
AID - jnnp.2006.113753 [pii]
AID - 10.1136/jnnp.2006.113753 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2008 Jan;79(1):47-51. doi: 
      10.1136/jnnp.2006.113753. Epub 2007 May 8.