PMID- 17489664
OWN - NLM
STAT- MEDLINE
DCOM- 20070529
LR  - 20071115
IS  - 1744-8344 (Electronic)
IS  - 1477-9072 (Linking)
VI  - 5
IP  - 3
DP  - 2007 May
TI  - Enoxaparin in acute coronary syndromes.
PG  - 387-99
AB  - Enoxaparin is a low-molecular-weight heparin (LMWH) derivative that exerts its 
      anticoagulant activity through antithrombin III, an endogenous inhibitor of 
      factor Xa and thrombin IIa. Unlike its unfractionated heparin (UFH) counterparts, 
      enoxaparin has a greater bioavailability, lower incidence of heparin-induced 
      thrombocytopenia and more stable and predictable anticoagulation, allowing fixed 
      dosing without the need for monitoring. These advantages make it an attractive 
      anticoagulant to be used in acute coronary syndrome management. Indeed, several 
      clinical trials and meta-analyses have consistently demonstrated the efficacy of 
      enoxaparin in reducing cardiovascular events and mortality in this population. 
      Although initial clinical trials with enoxaparin during the early conservative 
      approach suggested superior efficacy without differences in safety compared with 
      UFH, emerging data in the current era of early revascularization approach 
      indicate that superior effects of enoxaparin over heparin in reducing clinical 
      events should be balanced against an increase in major hemorrhagic complications. 
      Enoxaparin is a rational alternative to UFH in patients presenting with either 
      unstable angina/non-ST-elevation myocardial infarction or ST-elevation myocardial 
      infarction, with a clinically modest increase in bleeding complications.
FAU - Lee, Sinjin
AU  - Lee S
AD  - Beth Israel Deaconess Medical Center, Division of Cardiology, Boston, MA 02215, 
      USA. sjlee@bidmc.harvard.edu
FAU - Gibson, C Michael
AU  - Gibson CM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Rev Cardiovasc Ther
JT  - Expert review of cardiovascular therapy
JID - 101182328
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
SB  - IM
MH  - Angina, Unstable/*drug therapy
MH  - Anticoagulants/adverse effects/pharmacokinetics/pharmacology/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Enoxaparin/adverse effects/pharmacokinetics/pharmacology/*therapeutic use
MH  - Humans
MH  - Myocardial Infarction/*drug therapy
RF  - 56
EDAT- 2007/05/11 09:00
MHDA- 2007/05/30 09:00
CRDT- 2007/05/11 09:00
PHST- 2007/05/11 09:00 [pubmed]
PHST- 2007/05/30 09:00 [medline]
PHST- 2007/05/11 09:00 [entrez]
AID - 10.1586/14779072.5.3.387 [doi]
PST - ppublish
SO  - Expert Rev Cardiovasc Ther. 2007 May;5(3):387-99. doi: 10.1586/14779072.5.3.387.