PMID- 17489711
OWN - NLM
STAT- MEDLINE
DCOM- 20070628
LR  - 20221207
IS  - 1044-5463 (Print)
IS  - 1044-5463 (Linking)
VI  - 17
IP  - 2
DP  - 2007 Apr
TI  - Tolerability of selective serotonin reuptake inhibitors in thirty-nine children 
      under age seven: a retrospective chart review.
PG  - 165-74
AB  - OBJECTIVE: To characterize the adverse effects of treatment with selective 
      serotonin reuptake inhibitors (SSRIs) started in children under age 7 yr. 
      METHODS: We conducted a retrospective review of medical records for all children 
      who had begun treatment with an SSRI under age 7 at an academic psychiatry 
      department in Boston. RESULTS: Thirty-nine children (26 males, 13 females) met 
      the inclusion criteria. Mean age at start of treatment was 5.9 +/- 0.8 yr, and 
      median treatment duration was 5.0 months. The target diagnoses for SSRI treatment 
      were anxiety disorders in 54%, depressive disorders in 23%, and both anxiety and 
      depressive disorders in 20% of patients. There were no reports of suicidal 
      ideation or attempt. No children were medically or psychiatrically hospitalized 
      for adverse effects (AEs). Eleven patients (28%) reported an AE of at least 
      moderate severity; 7 (18%) discontinued the SSRI due to the AE. Six patients 
      discontinued due to behavioral activation and 1 due to gastrointestinal upset. 
      The median time to onset of an AE was 23 days, and median resolution was 19 days 
      from onset. CONCLUSIONS: The high rate of adverse effects, especially activation, 
      in this sample argues for continued caution in using SSRIs in young children. 
      Controlled trials are warranted.
FAU - Zuckerman, Marcia L
AU  - Zuckerman ML
AD  - Psychopharmacology Program, Department of Psychiatry, Children's Hospital Boston 
      and Harvard Medical School, MA 02115, USA.
FAU - Vaughan, Brigid L
AU  - Vaughan BL
FAU - Whitney, Jane
AU  - Whitney J
FAU - Dodds, Alice
AU  - Dodds A
FAU - Yakhkind, Aleksandra
AU  - Yakhkind A
FAU - MacMillan, Carlene
AU  - MacMillan C
FAU - Raches, Darcy
AU  - Raches D
FAU - Pravdova, Iva
AU  - Pravdova I
FAU - DeMaso, David Ray
AU  - DeMaso DR
FAU - Beardslee, William R
AU  - Beardslee WR
FAU - Gonzalez-Heydrich, Joseph
AU  - Gonzalez-Heydrich J
LA  - eng
GR  - K23 MH066835-02/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Child Adolesc Psychopharmacol
JT  - Journal of child and adolescent psychopharmacology
JID - 9105358
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Affective Symptoms/chemically induced
MH  - Age Factors
MH  - Aggression/drug effects
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gastrointestinal Diseases/chemically induced
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hyperkinesis/chemically induced
MH  - Male
MH  - Mental Disorders/*drug therapy/genetics
MH  - Retrospective Studies
MH  - Selective Serotonin Reuptake Inhibitors/*adverse effects
EDAT- 2007/05/11 09:00
MHDA- 2007/06/29 09:00
CRDT- 2007/05/11 09:00
PHST- 2007/05/11 09:00 [pubmed]
PHST- 2007/06/29 09:00 [medline]
PHST- 2007/05/11 09:00 [entrez]
AID - 10.1089/cap.2007.0086 [doi]
PST - ppublish
SO  - J Child Adolesc Psychopharmacol. 2007 Apr;17(2):165-74. doi: 
      10.1089/cap.2007.0086.