PMID- 17489730
OWN - NLM
STAT- MEDLINE
DCOM- 20090119
LR  - 20070510
IS  - 1744-8352 (Electronic)
IS  - 1473-7159 (Linking)
VI  - 7
IP  - 3
DP  - 2007 May
TI  - PNA FISH: present and future impact on patient management.
PG  - 231-6
AB  - Inappropriate and inaccurate antimicrobial therapy can lead to adverse patient 
      outcomes and also the development of antimicrobial resistance. Peptide nucleic 
      acid (PNA) fluorescence in situ hybridization (FISH) gives rapid reporting with 
      highly sensitive and specific results to clinicians within 3 h after blood 
      cultures turn positive, thereby offering targeted therapeutics where necessary. 
      It is simple to establish compared with real-time PCR and has resulted in 
      significant cost savings for hospitals. PNA FISH is a promising future technology 
      for the microbiology laboratory that will impact on patient management and 
      clinical guidelines. This article will review the clinical data supporting these 
      new technologies.
FAU - Forrest, Graeme N
AU  - Forrest GN
AD  - University of Maryland, Division of Infectious Diseases, Baltimore, MD 21201, 
      USA. gforrest@medicine.umaryland.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Rev Mol Diagn
JT  - Expert review of molecular diagnostics
JID - 101120777
RN  - 0 (Peptide Nucleic Acids)
SB  - IM
MH  - Bacterial Infections/*diagnosis/economics/*therapy
MH  - Candidiasis/*diagnosis/economics/*therapy
MH  - *Forecasting
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/economics/methods/*trends
MH  - *Peptide Nucleic Acids
MH  - Reproducibility of Results
MH  - Reverse Transcriptase Polymerase Chain Reaction/trends
RF  - 44
EDAT- 2007/05/11 09:00
MHDA- 2009/01/20 09:00
CRDT- 2007/05/11 09:00
PHST- 2007/05/11 09:00 [pubmed]
PHST- 2009/01/20 09:00 [medline]
PHST- 2007/05/11 09:00 [entrez]
AID - 10.1586/14737159.7.3.231 [doi]
PST - ppublish
SO  - Expert Rev Mol Diagn. 2007 May;7(3):231-6. doi: 10.1586/14737159.7.3.231.