PMID- 17489940
OWN - NLM
STAT- MEDLINE
DCOM- 20070629
LR  - 20221207
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 115
IP  - 5
DP  - 2007 May
TI  - Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian 
      multiple sclerosis patients.
PG  - 306-11
AB  - OBJECTIVE: The present study focused on human leukocyte antigen (HLA) DQB1, DQA1 
      and DRB1 allelic variation according to ethnicity and analyzed whether 
      susceptibility to multiple sclerosis (MS) depends on population characteristics. 
      METHODS: Eighty-eight healthy African-Brazilians and 92 healthy white Brazilians 
      living in Rio de Janeiro City were selected and the HLA phenotype between the two 
      ethnic groups was compared with 44 MS patients of African descent and 40 patients 
      of European descent. HLA class II genes were performed using polymerase chain 
      reaction (PCR) and PCR-sequence-specific primer amplification. RESULTS: 
      DQA1*0201-0301 alleles were associated with the white Brazilian population (P < 
      0.001). The DRB*1501 allele was present in White Brazilians (P=0.003), and 
      DRB1*03-1503 in African-Brazilians. The DRB1*1501 allele confers an 
      ethnicity-dependent MS susceptibility in White patients and the DQB1*0602 allele 
      confers genetic susceptibility regardless of ethnicity. CONCLUSION: Heterogeneous 
      phenotypes occur in both Brazilian ethnic groups. Taking into account that the 
      response to immunomodulator drugs for MS treatment changes according to the 
      DRB1*1501 allele and African-American MS patients presented poor response to the 
      interferons, phenotype heterogeneity of HLA loci found in this study could 
      influence therapeutic decisions in the Brazilian MS population.
FAU - Alves-Leon, S V
AU  - Alves-Leon SV
AD  - Neurology Department, Federal University of Rio de Janeiro State (UNIRIO), Rio de 
      Janeiro, Brazil. sonizavleon@globo.com
FAU - Papais-Alvarenga, R
AU  - Papais-Alvarenga R
FAU - Magalhaes, M
AU  - Magalhaes M
FAU - Alvarenga, M
AU  - Alvarenga M
FAU - Thuler, L C S
AU  - Thuler LC
FAU - Fernandez y Fernandez, O
AU  - Fernandez y Fernandez O
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (Antineoplastic Agents)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Antineoplastic Agents/therapeutic use
MH  - Black People/*genetics/statistics & numerical data
MH  - Brazil/epidemiology
MH  - Drug Resistance/genetics
MH  - Female
MH  - Genetic Heterogeneity
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Interferons/therapeutic use
MH  - Male
MH  - Multiple Sclerosis/drug therapy/*ethnology/*genetics
MH  - Phenotype
MH  - White People/*genetics/statistics & numerical data
EDAT- 2007/05/11 09:00
MHDA- 2007/06/30 09:00
CRDT- 2007/05/11 09:00
PHST- 2007/05/11 09:00 [pubmed]
PHST- 2007/06/30 09:00 [medline]
PHST- 2007/05/11 09:00 [entrez]
AID - ANE750 [pii]
AID - 10.1111/j.1600-0404.2006.00750.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2007 May;115(5):306-11. doi: 10.1111/j.1600-0404.2006.00750.x.