PMID- 17490536
OWN - NLM
STAT- MEDLINE
DCOM- 20071030
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 15
IP  - 1
DP  - 2007 Feb
TI  - [Cytogenetic analysis in patients with polycythemia vera].
PG  - 121-4
AB  - In order to evaluate the incidence of chromosomal abnormalities in patients with 
      polycythemia vera (PV) accurately and to investigate the value of fluorescence in 
      situ hybridization (FISH) technique in the detection of trisomies 8 and 9, 
      conventional cytogenetics (CC) technique was used to detect karyotype and 
      interphase FISH was used to detect trisomies 8 and 9 in 50 newly diagnosed PV and 
      8 normal individuals. The results showed that out of 50 cases, the 3 cases had 
      chromosome karyotype abnormality, including trisomy 8, deletion of chromosome Y 
      and inversion of chromosome 11 by CC technique. FISH method detected two cases of 
      trisomy 8, including one case confirmed by CC technique, and one case of trisomy 
      9 neglected by CC technique. It is concluded that the incidence of chromosomal 
      abnormalities in patients with PV is rare, and the incidence of trisomy 8 and 
      trisomy 9 found in this study are relatively lower than that have been reported 
      which may be related to the limited number of samples. Interphase FISH, as an 
      important complement to CC, is a useful method for the detection of trisomies 8 
      and 9.
FAU - Duan, Li-Min
AU  - Duan LM
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Li, Jian-Yong
AU  - Li JY
FAU - Pan, Jin-Lan
AU  - Pan JL
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Zhang, Su-Jiang
AU  - Zhang SJ
FAU - Wu, Ya-Fang
AU  - Wu YF
FAU - Xu, Wei
AU  - Xu W
FAU - Xue, Yong-Quan
AU  - Xue YQ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Gene Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Polycythemia Vera/*genetics
MH  - *Trisomy
EDAT- 2007/05/11 09:00
MHDA- 2007/10/31 09:00
CRDT- 2007/05/11 09:00
PHST- 2007/05/11 09:00 [pubmed]
PHST- 2007/10/31 09:00 [medline]
PHST- 2007/05/11 09:00 [entrez]
AID - 1009-2137(2007)01-0121-04 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Feb;15(1):121-4.