PMID- 17490652
OWN - NLM
STAT- MEDLINE
DCOM- 20070817
LR  - 20181113
IS  - 0014-4886 (Print)
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 206
IP  - 1
DP  - 2007 Jul
TI  - Caloric restriction eliminates the aging-related decline in NMDA and AMPA 
      receptor subunits in the rat hippocampus and induces homeostasis.
PG  - 70-9
AB  - Caloric restriction (CR) extends life span and ameliorates the aging-related 
      decline in hippocampal-dependent cognitive function. In the present study, we 
      compared subunit levels of NMDA and AMPA types of the glutamate receptor and 
      quantified total synapses and multiple spine bouton (MSB) synapses in hippocampal 
      CA1 from young (10 months), middle-aged (18 months), and old (29 months) Fischer 
      344xBrown Norway rats that were ad libitum (AL) fed or caloric restricted (CR) 
      from 4 months of age. Each of these parameters has been reported to be a 
      potential contributor to hippocampal function. Western blot analysis revealed 
      that NMDA and AMPA receptor subunits in AL animals decrease between young and 
      middle age to levels that are present at old age. Interestingly, young CR animals 
      have significantly lower levels of glutamate receptor subunits than young AL 
      animals and those lower levels are maintained across life span. In contrast, 
      stereological quantification indicated that total synapses and MSB synapses are 
      stable across life span in both AL and CR rats. These results indicate 
      significant aging-related losses of hippocampal glutamate receptor subunits in AL 
      rats that are consistent with altered synaptic function. CR eliminates that 
      aging-related decline by inducing stable NMDA and AMPA receptor subunit levels.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, 
      Medical Center Boulevard, Winston-Salem, NC 27157-1010, USA. lshi@wfubmc.edu
FAU - Adams, Michelle M
AU  - Adams MM
FAU - Linville, M Constance
AU  - Linville MC
FAU - Newton, Isabel G
AU  - Newton IG
FAU - Forbes, M Elizabeth
AU  - Forbes ME
FAU - Long, Ashley B
AU  - Long AB
FAU - Riddle, David R
AU  - Riddle DR
FAU - Brunso-Bechtold, Judy K
AU  - Brunso-Bechtold JK
LA  - eng
GR  - R01 AG019886-05/AG/NIA NIH HHS/United States
GR  - R01 AG019886/AG/NIA NIH HHS/United States
GR  - P01 AG011370-150003/AG/NIA NIH HHS/United States
GR  - AG019886/AG/NIA NIH HHS/United States
GR  - R01 AG019886-03/AG/NIA NIH HHS/United States
GR  - P01 AG011370/AG/NIA NIH HHS/United States
GR  - AG11370/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070404
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Glutamate)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Cognition Disorders/metabolism/physiopathology/*prevention & control
MH  - Dendritic Spines/metabolism/ultrastructure
MH  - Down-Regulation/physiology
MH  - Hippocampus/*metabolism/physiopathology/ultrastructure
MH  - Homeostasis/*physiology
MH  - Longevity/physiology
MH  - Male
MH  - Memory Disorders/metabolism/physiopathology/*prevention & control
MH  - Microscopy, Electron, Transmission
MH  - Protein Subunits/metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, AMPA/metabolism
MH  - Receptors, Glutamate/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Synapses/metabolism/ultrastructure
MH  - Synaptic Transmission/physiology
PMC - PMC2805133
MID - NIHMS26968
EDAT- 2007/05/11 09:00
MHDA- 2007/08/19 09:00
PMCR- 2010/01/12
CRDT- 2007/05/11 09:00
PHST- 2007/01/29 00:00 [received]
PHST- 2007/03/26 00:00 [revised]
PHST- 2007/03/29 00:00 [accepted]
PHST- 2007/05/11 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/05/11 09:00 [entrez]
PHST- 2010/01/12 00:00 [pmc-release]
AID - S0014-4886(07)00138-0 [pii]
AID - 10.1016/j.expneurol.2007.03.026 [doi]
PST - ppublish
SO  - Exp Neurol. 2007 Jul;206(1):70-9. doi: 10.1016/j.expneurol.2007.03.026. Epub 2007 
      Apr 4.