PMID- 17490670
OWN - NLM
STAT- MEDLINE
DCOM- 20071004
LR  - 20161229
IS  - 0020-7292 (Print)
IS  - 0020-7292 (Linking)
VI  - 98
IP  - 1
DP  - 2007 Jul
TI  - Expression of human leukocyte antigen-G and its correlation with interleukin-10 
      expression in cervical carcinoma.
PG  - 48-53
AB  - OBJECTIVE: To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 
      expression and the relationship between HLA-G expression and clinicopathologic 
      features in patients with cervical cancer. METHOD: Tissue samples were obtained 
      from 40 patients with cervical cancer and 15 control patients with a normal 
      cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for 
      protein expression were used. RESULT: Both HLA-G and IL-10 mRNA expression in 
      cervical cancer tissues was significantly greater than normal controls (P<0.001, 
      P=0.005). Protein expression of HLA-G and IL-10 in the cancer group was also 
      significantly greater than in the controls (P<0.001, P=0.021). There was an 
      inverse relationship between FIGO stage and HLA-G mRNA expression (P=0.046). 
      CONCLUSION: HLA-G and IL-10 might play an important role in cancer progression of 
      the cervix. High HLA-G mRNA expression may be related to early carcinogenesis 
      since it was associated with early-stage cervical cancer.
FAU - Yoon, B S
AU  - Yoon BS
AD  - Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA 
      University, Seoul, Korea.
FAU - Kim, Y T
AU  - Kim YT
FAU - Kim, J W
AU  - Kim JW
FAU - Kim, S H
AU  - Kim SH
FAU - Kim, J H
AU  - Kim JH
FAU - Kim, S W
AU  - Kim SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070509
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the 
      International Federation of Gynaecology and Obstetrics
JID - 0210174
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (RNA, Messenger)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blotting, Western
MH  - Carcinoma
MH  - Carcinoma, Squamous Cell
MH  - Female
MH  - *Gene Expression
MH  - HLA Antigens/*metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Interleukin-10/*metabolism
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - RNA, Messenger/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Uterine Cervical Neoplasms/immunology/*pathology
EDAT- 2007/05/11 09:00
MHDA- 2007/10/05 09:00
CRDT- 2007/05/11 09:00
PHST- 2006/11/21 00:00 [received]
PHST- 2007/03/26 00:00 [revised]
PHST- 2007/03/26 00:00 [accepted]
PHST- 2007/05/11 09:00 [pubmed]
PHST- 2007/10/05 09:00 [medline]
PHST- 2007/05/11 09:00 [entrez]
AID - S0020-7292(07)00200-7 [pii]
AID - 10.1016/j.ijgo.2007.03.041 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2007 Jul;98(1):48-53. doi: 10.1016/j.ijgo.2007.03.041. 
      Epub 2007 May 9.