PMID- 17490958
OWN - NLM
STAT- MEDLINE
DCOM- 20070614
LR  - 20230318
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 85
IP  - 5
DP  - 2007 May
TI  - Effects of low- and high-advanced glycation endproduct meals on macro- and 
      microvascular endothelial function and oxidative stress in patients with type 2 
      diabetes mellitus.
PG  - 1236-43
AB  - BACKGROUND: An advanced glycation endproducts (AGEs)-rich diet induces 
      significant increases in inflammatory and endothelial dysfunction markers in type 
      2 diabetes mellitus (T2DM). OBJECTIVE: The aim was to investigate the acute 
      effects of dietary AGEs on vascular function in T2DM patients. DESIGN: Twenty 
      inpatients with T2DM [x (+/-SEM) age: 55.4 +/- 2.2 y; glycated hemoglobin: 8.8 
      +/- 0.5%] were investigated. In a randomized crossover design, the effects of a 
      low-AGE (LAGE) and high-AGE (HAGE) meal on macrovascular [by flow-mediated 
      dilatation (FMD)] and microvascular (by Laser-Doppler flowmetry) function, serum 
      markers of endothelial dysfunction (E-selectin, intracellular adhesion molecule 
      1, and vascular cell adhesion molecule 1), oxidative stress, and serum AGE were 
      assessed. The meals had identical ingredients but different AGE amounts (15.100 
      compared with 2.750 kU AGE for the HAGE and LAGE meals, respectively), which were 
      obtained by varying the cooking temperature and time. The measurements were 
      performed at baseline and 2, 4, and 6 h after each meal. RESULTS: After the HAGE 
      meal, FMD decreased by 36.2%, from 5.77 +/- 0.65% (baseline) to 3.93 +/- 0.48 (2 
      h), 3.70 +/- 0.42 (4 h), and 4.42 +/- 0.54% (6 h) (P<0.01 for all compared with 
      baseline). After the LAGE meal, FMD decreased by 20.9%, from 6.04 +/- 0.68% 
      (baseline) to 4.75 +/- 0.48% (2 h), 4.69 +/- 0.51% (4 h), and 5.62 +/- 0.63% (6 
      h), respectively (P<0.01 for all compared with baseline; P<0.001 for all compared 
      with the HAGE meal). This impairment of macrovascular function after the HAGE 
      meal was paralleled by an impairment of microvascular function (-67.2%) and 
      increased concentrations of serum AGE and markers of endothelial dysfunction and 
      oxidative stress. CONCLUSIONS: In patients with T2DM, a HAGE meal induces a more 
      pronounced acute impairment of vascular function than does an otherwise identical 
      LAGE meal. Therefore, chemical modifications of food by means of cooking play a 
      major role in influencing the extent of postprandial vascular dysfunction.
FAU - Negrean, Monica
AU  - Negrean M
AD  - Diabetes Clinic, Heart and Diabetes Centre NRW Bad Oeynhausen, Ruhr University 
      Bochum, Germany.
FAU - Stirban, Alin
AU  - Stirban A
FAU - Stratmann, Bernd
AU  - Stratmann B
FAU - Gawlowski, Thomas
AU  - Gawlowski T
FAU - Horstmann, Tina
AU  - Horstmann T
FAU - Gotting, Christian
AU  - Gotting C
FAU - Kleesiek, Knut
AU  - Kleesiek K
FAU - Mueller-Roesel, Michaela
AU  - Mueller-Roesel M
FAU - Koschinsky, Theodor
AU  - Koschinsky T
FAU - Uribarri, Jaime
AU  - Uribarri J
FAU - Vlassara, Helen
AU  - Vlassara H
FAU - Tschoepe, Diethelm
AU  - Tschoepe D
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Biomarkers)
RN  - 0 (E-Selectin)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
SB  - IM
EIN - Am J Clin Nutr. 2007 Oct;86(4):1256
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 2/blood/*metabolism
MH  - E-Selectin/blood
MH  - Endothelium, Vascular/*drug effects/*physiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Glycation End Products, Advanced/*administration & dosage/blood
MH  - Humans
MH  - Laser-Doppler Flowmetry/methods
MH  - Male
MH  - Microcirculation/drug effects
MH  - Middle Aged
MH  - Oxidative Stress/*drug effects
MH  - Vascular Cell Adhesion Molecule-1/blood
MH  - Vasodilation/drug effects/physiology
EDAT- 2007/05/11 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/05/11 09:00
PHST- 2007/05/11 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/05/11 09:00 [entrez]
AID - S0002-9165(23)28059-4 [pii]
AID - 10.1093/ajcn/85.5.1236 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2007 May;85(5):1236-43. doi: 10.1093/ajcn/85.5.1236.