PMID- 17491351
OWN - NLM
STAT- MEDLINE
DCOM- 20071030
LR  - 20181113
IS  - 1863-6705 (Print)
IS  - 1863-6705 (Linking)
VI  - 55
IP  - 4
DP  - 2007 Apr
TI  - Completely pulsatile high flow circulatory support with a constant-speed 
      centrifugal blood pump: mechanisms and early clinical observations.
PG  - 158-62
AB  - OBJECTIVE: Various types of rotary blood pumps (axial flow, centrifugal) have 
      been introduced into clinical use recently. These pumps have different 
      pressure-flow characteristics, and some investigators have noted that a limited 
      pump flow rate and less pulsatility are the problems with the axial flow devices. 
      METHODS: A new implantable centrifugal blood pump was developed that has an 
      extremely flat pressure-flow curve and is able to produce a significantly high 
      pump flow rate of 20 l/min at a low pressure of 10-30mmHg. When the pressure 
      difference between the left ventricle and aorta decreases during systole, an 
      instant high peak flow is achieved, which results in a higher peak pressure in 
      the aorta (systolic pressure). During the diastolic phase, the left 
      ventricle-aorta pressure difference increases to maximum, and the pump flow rate 
      decreases to minimum. Thus, the pump flow rate becomes completely pulsatile, and 
      the high peak flow provides a higher mean pump flow rate. This pump was applied 
      to two end-stage heart failure patients (dilated cardiomyopathy, New York Heart 
      Association (NYHA) class IV, inotrope-dependent). RESULTS: The pump was observed 
      to provide completely pulsatile high flow assistance of 6-9 l/min with a constant 
      pump speed. Both patients are currently in NYHA class I after 1 year on the 
      device with no major adverse events. CONCLUSION: The new centrifugal blood pump 
      provides completely pulsatile high-flow circulatory support with a constant pump 
      speed, which solves the current clinical problems with rotary blood pumps.
FAU - Yamazaki, Kenji
AU  - Yamazaki K
AD  - Department of Cardiovascular Surgery, Tokyo Women's Medical University, 
      Kawada-cho, Shinjuku-ku, Japan. syamazak@hij.twmu.ac.jp
FAU - Saito, Satoshi
AU  - Saito S
FAU - Kihara, Shinichiro
AU  - Kihara S
FAU - Tagusari, Osamu
AU  - Tagusari O
FAU - Kurosawa, Hiromi
AU  - Kurosawa H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Gen Thorac Cardiovasc Surg
JT  - General thoracic and cardiovascular surgery
JID - 101303952
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/therapy
MH  - Equipment Design
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulsatile Flow
EDAT- 2007/05/12 09:00
MHDA- 2007/10/31 09:00
CRDT- 2007/05/12 09:00
PHST- 2007/05/12 09:00 [pubmed]
PHST- 2007/10/31 09:00 [medline]
PHST- 2007/05/12 09:00 [entrez]
AID - 10.1007/s11748-007-0098-6 [doi]
PST - ppublish
SO  - Gen Thorac Cardiovasc Surg. 2007 Apr;55(4):158-62. doi: 
      10.1007/s11748-007-0098-6.