PMID- 17491688
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070810
LR  - 20200622
IS  - 1614-0575 (Electronic)
IS  - 1613-6071 (Print)
IS  - 1613-6071 (Linking)
VI  - 2
IP  - 3
DP  - 2005 Fall
TI  - High-fat feeding during gestation and nursing period have differential effects on 
      the insulin secretory capacity in offspring from normal Wistar rats.
PG  - 136-45
AB  - Restriction of protein or energy intake during gestation or early life is linked 
      to developmental defects in the endocrine pancreas and insulin resistance. AIMS: 
      To study whether a saturated fatty acid-rich diet during gestation and/or after 
      the weaning period may be detrimental to the insulin secretory capacity later in 
      life. STUDY DESIGN: Female Wistar rats were fed diets rich in carbohydrate (CHO) 
      or saturated fat (SAFA) during pregnancy. The male offspring were split into five 
      subgroups: after birth group 1 (control) continued on CHO and group 3 on SAFA. 
      Group 2 continued on the CHO diet during the nursing period but changed to SAFA 
      post weaning. Group 4 continued on SAFA, but changed to CHO post weaning. For 
      group 5 the offspring of mothers given a SAFA diet were changed to nursing 
      mothers on a CHO diet immediately after birth, and continued on the same diet 
      post weaning. After 14 wk, the islets of Langerhans were isolated for 
      determination of insulin secretory capacity in static incubation and dynamic 
      perifusion experiments. RESULTS: We found a negative correlation (Coef: -3.1, 95% 
      CI: -6.1 to -0.0, p < 0.05) between a diet rich in saturated fat fed to mothers 
      during gestation and a positive correlation (Coef: 4.4, 95% CI: 0.9 to 7.8, p = 
      0.01) between nursing mothers' diet and the capability to secrete insulin in the 
      offspring. CONCLUSION: Our results indicate the importance of applying a 
      nutrient-balanced diet during pregnancy and the nursing period on the later 
      insulin secretory capacity in the offspring.
FAU - Dyrskog, Stig E U
AU  - Dyrskog SE
AD  - Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus 
      University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark. 
      stig.dyrskog@ki.au.dk
FAU - Gregersen, Soren
AU  - Gregersen S
FAU - Hermansen, Kjeld
AU  - Hermansen K
LA  - eng
PT  - Journal Article
DEP - 20051110
PL  - Singapore
TA  - Rev Diabet Stud
JT  - The review of diabetic studies : RDS
JID - 101227575
PMC - PMC1783557
EDAT- 2007/05/12 09:00
MHDA- 2007/05/12 09:01
PMCR- 2006/09/01
CRDT- 2007/05/12 09:00
PHST- 2007/05/12 09:00 [pubmed]
PHST- 2007/05/12 09:01 [medline]
PHST- 2007/05/12 09:00 [entrez]
PHST- 2006/09/01 00:00 [pmc-release]
AID - 10.1900/RDS.2005.2.136 [doi]
PST - ppublish
SO  - Rev Diabet Stud. 2005 Fall;2(3):136-45. doi: 10.1900/RDS.2005.2.136. Epub 2005 
      Nov 10.