PMID- 17492939
OWN - NLM
STAT- MEDLINE
DCOM- 20070815
LR  - 20181113
IS  - 1470-8728 (Electronic)
IS  - 0264-6021 (Print)
IS  - 0264-6021 (Linking)
VI  - 406
IP  - 1
DP  - 2007 Aug 15
TI  - Polyphosphate blocks tumour metastasis via anti-angiogenic activity.
PG  - 49-55
AB  - PolyP (inorganic polyphosphate) is a linear polymer of many tens or hundreds of 
      orthophosphate residues found in a wide range of organisms, including bacteria, 
      fungi, insects, plants and vertebrates. Despite its wide distribution in 
      mammalian tissues and plasma, the biological functions of polyP on tumour 
      metastasis and angiogenesis have not been previously examined. In the present 
      study, we have shown that polyP effectively blocked in vivo pulmonary metastasis 
      of B16BL6 cells by suppression of neovascularization, whereas it did not affect 
      proliferation or adhesion to extracellular matrix proteins. PolyP not only 
      inhibited bFGF (basic fibroblast growth factor)-induced proliferation and ERK 
      (extracellular-signal-regulated kinase)/p38 MAPK (mitogen-activated protein 
      kinase) activation of human endothelial cells, but also blocked the binding of 
      bFGF to its cognate cell-surface receptor. Furthermore, polyP inhibited 
      bFGF-induced in vitro and in vivo angiogenesis, suggesting that polyP possesses 
      an anti-angiogenic activity. Since neovascularization is essential for tumour 
      metastasis, our present findings clearly indicate that polyP has an in vivo 
      anti-metastatic activity via its anti-angiogenic activity. Taken together with 
      the fact that angiogenesis occurs under various normal and pathological 
      conditions, our observations suggest that endogenous polyP may play a critical 
      role during embryonic development, wound healing and inflammation, as well as in 
      the progress of pathological diseases such as rheumatoid arthritis and cancer.
FAU - Han, Kyu Yeon
AU  - Han KY
AD  - Division of Molecular and Life Sciences, Pohang University of Science and 
      Technology, Pohang 790-784, Republic of Korea.
FAU - Hong, Bok Sil
AU  - Hong BS
FAU - Yoon, Yae Jin
AU  - Yoon YJ
FAU - Yoon, Chang Min
AU  - Yoon CM
FAU - Kim, Yoon-Keun
AU  - Kim YK
FAU - Kwon, Young-Guen
AU  - Kwon YG
FAU - Gho, Yong Song
AU  - Gho YS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - 0 (Polyphosphates)
RN  - 0 (Receptors, Cell Surface)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cell Adhesion/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - Endothelial Cells/drug effects/pathology
MH  - Enzyme Activation/drug effects
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Fibroblast Growth Factor 2/pharmacology
MH  - Humans
MH  - Lung Neoplasms/*blood supply/*secondary
MH  - Male
MH  - Melanoma/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasm Metastasis/*pathology
MH  - Neovascularization, Pathologic/*pathology
MH  - Polyphosphates/*pharmacology
MH  - Receptors, Cell Surface/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
PMC - PMC1948993
EDAT- 2007/05/12 09:00
MHDA- 2007/08/19 09:00
PMCR- 2008/02/15
CRDT- 2007/05/12 09:00
PHST- 2007/05/12 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/05/12 09:00 [entrez]
PHST- 2008/02/15 00:00 [pmc-release]
AID - BJ20061542 [pii]
AID - bj4060049 [pii]
AID - 10.1042/BJ20061542 [doi]
PST - ppublish
SO  - Biochem J. 2007 Aug 15;406(1):49-55. doi: 10.1042/BJ20061542.