PMID- 17493154
OWN - NLM
STAT- MEDLINE
DCOM- 20070711
LR  - 20070511
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 3
DP  - 2007 Mar
TI  - Identification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of 
      HLA-A*2631 in the Brazilian population.
PG  - 273-6
AB  - Two novel alleles, human leukocyte antigen (HLA)-B*3569, -B*4450 and a 
      confirmatory sequence of HLA-A*2631 were identified during a routine typing for 
      the Brazilian Bone Marrow Donor Registry. Sequence analysis of coding exons 2 and 
      3 revealed a single nucleotide substitution in HLA-B*3569 and two single 
      nucleotide substitutions in HLA-B*4450, compared with closely related alleles. At 
      the protein level, these substitutions result in a change of a single amino acid 
      residue in each of HLA-B*3569 and -B*4450 at positions 74 (Arg > Pro) and 80 (Thr 
      > Ile), respectively. These variations are located in the highly polymorphic 
      region at the end of the alpha(1) domain of the HLA molecule. It appears that 
      HLA-B*3569 arose from the analogous HLA-B*3510 through a point mutation. However, 
      HLA-B*4450 may have arisen from HLA-B*440301 and -B*4425 by gene conversion.
FAU - Abdeen, H
AU  - Abdeen H
AD  - Northern Ireland Histocompatibility and Immunogenetics Laboratory, Belfast City 
      Hospital, Belfast, UK. hesham.abdeen@bll.n-i.nhs.uk
FAU - McErlean, C
AU  - McErlean C
FAU - Moraes, M E
AU  - Moraes ME
FAU - Romero, M
AU  - Romero M
FAU - Marques, S B
AU  - Marques SB
FAU - Goncales, A C
AU  - Goncales AC
FAU - Guariento, E G
AU  - Guariento EG
FAU - Middleton, D
AU  - Middleton D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - *Amino Acid Substitution
MH  - Brazil
MH  - Female
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Male
MH  - *Point Mutation
EDAT- 2007/05/12 09:00
MHDA- 2007/07/12 09:00
CRDT- 2007/05/12 09:00
PHST- 2007/05/12 09:00 [pubmed]
PHST- 2007/07/12 09:00 [medline]
PHST- 2007/05/12 09:00 [entrez]
AID - TAN788 [pii]
AID - 10.1111/j.1399-0039.2006.00788.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Mar;69(3):273-6. doi: 10.1111/j.1399-0039.2006.00788.x.