PMID- 17493602
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20070723
IS  - 0009-9120 (Print)
IS  - 0009-9120 (Linking)
VI  - 40
IP  - 12
DP  - 2007 Aug
TI  - Relationship between matrix metalloproteinases/tissue inhibitors of matrix 
      metalloproteinases systems and autoantibody patterns in systemic sclerosis.
PG  - 837-42
AB  - OBJECTIVE: Systemic sclerosis (SSc) is a connective tissue disease characterized 
      by tissue fibrosis that reflects an imbalance between collagen production and 
      degradation. Matrix metalloproteinases (MMPs) are a family of endopeptidases 
      involved in the remodelling of extracellular matrix (ECM). This activity is 
      controlled by tissue inhibitors of MMP (TIMPs). Aim of this study was the 
      evaluation of MMP-9/TIMP-1 and MMP-2/TIMP-2 systems in patients with SSc. DESIGN 
      AND METHODS: SearchLight Human MMP Array 1 was used to measure MMPs and TIMPs in 
      32 SSc patients and 32 matched healthy controls. RESULTS: SSc patients showed 
      higher values of both MMP-9 and TIMP-1 in comparison with controls. The patients 
      with anticentromere antibodies (ACA) positivity showed higher values of MMPs and 
      TIMPs in comparison with either controls or the patients with anti-Scl70-positive 
      antibodies. CONCLUSION: Results of this investigation suggest that SSc patients 
      with ACA positivity, after a primary fibrogenetic noxa, react with a more 
      abundant release of MMP/TIMP, whereas patients with anti-Scl70 antibody show a 
      normal response.
FAU - Montagnana, Martina
AU  - Montagnana M
AD  - Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze 
      Morfologico-Biomediche, Universita degli Studi di Verona, Ospedale Policlinico G 
      B Rossi, Piazzale Scuro, 10, Verona, Italy. martina.montagnana@med.lu.se
FAU - Volpe, Alessandro
AU  - Volpe A
FAU - Lippi, Giuseppe
AU  - Lippi G
FAU - Caramaschi, Paola
AU  - Caramaschi P
FAU - Salvagno, Gian Luca
AU  - Salvagno GL
FAU - Biasi, Domenico
AU  - Biasi D
FAU - Bambara, Lisa Maria
AU  - Bambara LM
FAU - Guidi, Gian Cesare
AU  - Guidi GC
LA  - eng
PT  - Journal Article
DEP - 20070419
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Autoantibodies)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*immunology
MH  - Case-Control Studies
MH  - Demography
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 2/metabolism
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Matrix Metalloproteinases/*metabolism
MH  - Middle Aged
MH  - Scleroderma, Systemic/*enzymology/*immunology
MH  - Tissue Inhibitor of Metalloproteinase-1/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-2/metabolism
MH  - Tissue Inhibitor of Metalloproteinases/*metabolism
EDAT- 2007/05/12 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/05/12 09:00
PHST- 2006/12/27 00:00 [received]
PHST- 2007/02/27 00:00 [revised]
PHST- 2007/03/27 00:00 [accepted]
PHST- 2007/05/12 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/05/12 09:00 [entrez]
AID - S0009-9120(07)00164-6 [pii]
AID - 10.1016/j.clinbiochem.2007.03.023 [doi]
PST - ppublish
SO  - Clin Biochem. 2007 Aug;40(12):837-42. doi: 10.1016/j.clinbiochem.2007.03.023. 
      Epub 2007 Apr 19.