PMID- 17493637
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20220317
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 260
IP  - 1-2
DP  - 2007 Sep 15
TI  - Evaluation of brain perfusion SPECT using an easy Z-score imaging system (eZIS) 
      as an adjunct to early-diagnosis of neurodegenerative diseases.
PG  - 57-64
AB  - The eZIS allows computer-assisted statistical analysis of brain perfusion SPECT 
      images. We evaluated the diagnostic value of brain perfusion SPECT using eZIS in 
      patients with various neurodegenerative diseases at a very early stage, within 
      one year from onset. METHODS: SPECT using eZIS was performed for patients with 
      Alzheimer disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia 
      (FTD,), idiopathic Parkinson disease (PD) and vascular Parkinsonism (VP), 
      multiple systemic atrophy of the cerebellar type (MSA-C), cortical cerebellar 
      atrophy (CCA) and amyotrophic lateral sclerosis (ALS). RESULTS: Decreased rCBF 
      was observed in the posterior cingulate cortex, precuneus and parietal cortex in 
      AD; in the frontal gyrus and insula in FTD; in the occipital lobe, precuneus 
      gyrus and posterior cingulate cortex in DLB; in the striatum and the thalamus in 
      VP; in the cerebellum in CCA; in the cerebellum and pons in MSA-C and in the 
      frontal cortex including the central sulcus in ALS. Increased rCBF in the 
      striatum, thalamus and cerebellar dentate nuclei were observed in PD. 
      CONCLUSIONS: A specific rCBF pattern was observed for each disease using eZIS 
      analysis, consistent with previous reports. Our results showed eZIS can be easily 
      used as an adjunct to early-diagnosis of neurodegenerative diseases in any 
      hospital.
FAU - Waragai, Masaaki
AU  - Waragai M
AD  - Division of Neurology, JR Tokyo General Hospital, 2-1-3, Yoyogi, Shibuya-ku, 
      Tokyo 151-8528, Japan. warawaram2002@aol.com
FAU - Yamada, Tatsuo
AU  - Yamada T
FAU - Matsuda, Hiroshi
AU  - Matsuda H
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20070509
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alzheimer Disease/diagnostic imaging/pathology/physiopathology
MH  - Amyotrophic Lateral Sclerosis/diagnostic imaging/pathology/physiopathology
MH  - Brain/blood supply/*diagnostic imaging/pathology
MH  - Brain Mapping/methods
MH  - Cerebrovascular Circulation/*physiology
MH  - Dementia/diagnostic imaging/pathology/physiopathology
MH  - Diagnosis, Differential
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Lewy Body Disease/diagnostic imaging/pathology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multiple System Atrophy/diagnostic imaging/pathology/physiopathology
MH  - Neurodegenerative Diseases/*diagnostic imaging/pathology/physiopathology
MH  - Parkinson Disease/diagnostic imaging/pathology/physiopathology
MH  - Predictive Value of Tests
MH  - Spinocerebellar Degenerations/diagnostic imaging/pathology/physiopathology
MH  - Tomography, Emission-Computed, Single-Photon/*methods
EDAT- 2007/05/12 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/05/12 09:00
PHST- 2006/12/13 00:00 [received]
PHST- 2007/03/24 00:00 [revised]
PHST- 2007/03/29 00:00 [accepted]
PHST- 2007/05/12 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/05/12 09:00 [entrez]
AID - S0022-510X(07)00269-9 [pii]
AID - 10.1016/j.jns.2007.03.027 [doi]
PST - ppublish
SO  - J Neurol Sci. 2007 Sep 15;260(1-2):57-64. doi: 10.1016/j.jns.2007.03.027. Epub 
      2007 May 9.