PMID- 17495259
OWN - NLM
STAT- MEDLINE
DCOM- 20070705
LR  - 20071115
IS  - 1074-2484 (Print)
IS  - 1074-2484 (Linking)
VI  - 12
IP  - 1
DP  - 2007 Mar
TI  - Short-term intra-arterial infusion of monocyte chemoattractant protein-1 results 
      in sustained collateral artery growth.
PG  - 61-8
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a stimulator of collateral artery 
      growth and has been shown to increase collateral artery conductance in rabbits 
      and pigs. The minimal infusion duration and the minimally effective dose of MCP-1 
      are currently unknown, as is the sustainability of the therapeutic effect over a 
      longer observation period than tested before. MCP-1 was infused intra-arterially 
      in pigs after unilateral femoral artery occlusion in different doses and infusion 
      durations between 2 hours and 2 weeks. Two weeks after ligation, arterial 
      conductance under maximal vasodilatation was measured. The long-term efficacy was 
      investigated in 2 additional groups of animals after 6 weeks. Infusion with 2 
      microg/min of MCP-1 for 6 hours was sufficient to double arterial conductance, 
      and arterial conductance after 6 weeks was still significantly increased.
FAU - Seidler, Randolph W
AU  - Seidler RW
AD  - Department of Cardiovascular Disease, Boehringer Ingelheim Pharmaceuticals Inc., 
      900 Ridgebury Road, Ridgefield, CT 06877, USA. 
      rseidler@rdg.boehringer-ingelheim.com
FAU - Lenter, Martin C
AU  - Lenter MC
FAU - Guth, Brian D
AU  - Guth BD
FAU - Doods, Henri
AU  - Doods H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Pharmacol Ther
JT  - Journal of cardiovascular pharmacology and therapeutics
JID - 9602617
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Arteries/*drug effects/growth & development/physiopathology
MH  - CHO Cells
MH  - Chemokine CCL2/administration & dosage/genetics/*pharmacology
MH  - Collateral Circulation/drug effects
MH  - Cricetinae
MH  - Cricetulus
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Femoral Artery/surgery
MH  - Humans
MH  - Infusions, Intra-Arterial
MH  - Ligation/adverse effects
MH  - Male
MH  - Peripheral Vascular Diseases/*drug therapy/etiology/physiopathology
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/genetics/physiology
MH  - Recombinant Proteins/administration & dosage/pharmacology
MH  - Swine
MH  - Swine, Miniature
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2007/05/15 09:00
MHDA- 2007/07/06 09:00
CRDT- 2007/05/15 09:00
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/07/06 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - 12/1/61 [pii]
AID - 10.1177/1074248406298625 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol Ther. 2007 Mar;12(1):61-8. doi: 10.1177/1074248406298625.