PMID- 17495977
OWN - NLM
STAT- MEDLINE
DCOM- 20070831
LR  - 20220419
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 21
IP  - 7
DP  - 2007 Jul
TI  - A comprehensive genetic and histopathologic analysis identifies two subgroups of 
      B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.
PG  - 1532-44
AB  - The biologic and pathologic features of B-cell malignancies bearing a 
      translocation t(14;19)(q32;q13) leading to a fusion of IGH and BCL3 are still 
      poorly described. Herein we report the results of a comprehensive cytogenetic, 
      fluorescence in situ hybridization (FISH), molecular and histopathological survey 
      of a large series of B-cell malignancies with t(14;19) or variant translocations. 
      A total of 56 B-cell malignancies with a FISH-proven BCL3 involvement were 
      identified with the translocation partners being IGH (n=51), IGL (n=2), IGK (n=2) 
      and a non-IG locus (n=1). Hierarchical clustering of chromosomal changes 
      associated with the t(14;19) indicated the presence of two different groups of 
      IG/BCL3-positive lymphatic neoplasias. The first group included 26 B-cell 
      malignancies of various histologic subtypes containing a relatively high number 
      of chromosomal changes and mostly mutated IgVH genes. This cluster displayed 
      three cytogenetic branches, one with rearrangements in 7q, another with deletions 
      in 17p and a third one with rearrangements in 1q and deletions in 6q and 13q. The 
      second group included 19 cases, mostly diagnosed as B-cell chronic lymphocytic 
      leukemia (B-CLL), and characterized by few additional chromosomal changes (e.g. 
      trisomy 12) and unmutated IgVH genes. In conclusion, our study indicates that 
      BCL3 translocations are not restricted to B-CLL but present in a heterogeneous 
      group of B-cell malignancies.
FAU - Martin-Subero, J I
AU  - Martin-Subero JI
AD  - Institute of Human Genetics, University Hospital Schleswig-Holstein Campus Kiel, 
      Christian-Albrechts University, Kiel, Germany.
FAU - Ibbotson, R
AU  - Ibbotson R
FAU - Klapper, W
AU  - Klapper W
FAU - Michaux, L
AU  - Michaux L
FAU - Callet-Bauchu, E
AU  - Callet-Bauchu E
FAU - Berger, F
AU  - Berger F
FAU - Calasanz, M J
AU  - Calasanz MJ
FAU - De Wolf-Peeters, C
AU  - De Wolf-Peeters C
FAU - Dyer, M J
AU  - Dyer MJ
FAU - Felman, P
AU  - Felman P
FAU - Gardiner, A
AU  - Gardiner A
FAU - Gascoyne, R D
AU  - Gascoyne RD
FAU - Gesk, S
AU  - Gesk S
FAU - Harder, L
AU  - Harder L
FAU - Horsman, D E
AU  - Horsman DE
FAU - Kneba, M
AU  - Kneba M
FAU - Kuppers, R
AU  - Kuppers R
FAU - Majid, A
AU  - Majid A
FAU - Parry-Jones, N
AU  - Parry-Jones N
FAU - Ritgen, M
AU  - Ritgen M
FAU - Salido, M
AU  - Salido M
FAU - Sole, F
AU  - Sole F
FAU - Thiel, G
AU  - Thiel G
FAU - Wacker, H-H
AU  - Wacker HH
FAU - Oscier, D
AU  - Oscier D
FAU - Wlodarska, I
AU  - Wlodarska I
FAU - Siebert, R
AU  - Siebert R
LA  - eng
GR  - MC_U132670597/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070510
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (B-Cell Lymphoma 3 Protein)
RN  - 0 (BCL3 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - B-Cell Lymphoma 3 Protein
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 19
MH  - Cytogenetic Analysis
MH  - Female
MH  - Gene Rearrangement
MH  - Genes, Immunoglobulin
MH  - Histocytochemistry
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, B-Cell/classification/*genetics/pathology
MH  - Lymphoma, B-Cell/classification/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins/*genetics
MH  - Transcription Factors/*genetics
MH  - *Translocation, Genetic
EDAT- 2007/05/15 09:00
MHDA- 2007/09/01 09:00
CRDT- 2007/05/15 09:00
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/09/01 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - 2404695 [pii]
AID - 10.1038/sj.leu.2404695 [doi]
PST - ppublish
SO  - Leukemia. 2007 Jul;21(7):1532-44. doi: 10.1038/sj.leu.2404695. Epub 2007 May 10.