PMID- 17496348
OWN - NLM
STAT- MEDLINE
DCOM- 20070917
LR  - 20191110
IS  - 0257-277X (Print)
IS  - 0257-277X (Linking)
VI  - 37
IP  - 1
DP  - 2007
TI  - Transcription factors in the control of dendritic cell life cycle.
PG  - 79-96
AB  - Dendritic cells (DCs) are potent antigen-presenting cells that guard all parts of 
      the body. They have the unique ability to prime T cells and generate primary 
      immune responses. Their journey beginning with the development from precursor 
      cells and ending with their death is controlled by a group of transcription 
      factors. Some of the transcription factors like PU.1 are involved in more than 
      one stage of DC life. Other transcription factors including Ikaros and JAK3 are 
      involved in the development of more than one cell type. For a long time, the 
      cellular and molecular mechanisms underlying the development, differentiation, 
      maturation, and other stages of DC life were not well understood. However, in 
      recent years novel information has been published by many researchers to better 
      understand the molecular mechanisms of the development and function of DCs in 
      immunological diseases such as asthma, cancer, autoimmunity, and transplantation. 
      This review will discuss the various transcription factors and signaling pathways 
      involved in each stage of the life cycle of DCs.
FAU - Bharadwaj, Arpita S
AU  - Bharadwaj AS
AD  - Department of Medical Microbiology and Immunology, Creighton University School of 
      Medicine, Omaha, NE 68178, USA.
FAU - Agrawal, Devendra K
AU  - Agrawal DK
LA  - eng
GR  - R01 HL 070885/HL/NHLBI NIH HHS/United States
GR  - R01 HL 073349/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (proto-oncogene protein Spi-1)
RN  - 148971-36-2 (Ikaros Transcription Factor)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - *Cell Differentiation
MH  - Dendritic Cells/*cytology/immunology
MH  - Humans
MH  - Ikaros Transcription Factor/metabolism
MH  - Mice
MH  - Proto-Oncogene Proteins/metabolism
MH  - *Signal Transduction
MH  - Trans-Activators/metabolism
MH  - Transcription Factors/*metabolism
RF  - 106
EDAT- 2007/05/15 09:00
MHDA- 2007/09/18 09:00
CRDT- 2007/05/15 09:00
PHST- 1999/11/30 00:00 [received]
PHST- 1999/11/30 00:00 [revised]
PHST- 1999/11/30 00:00 [accepted]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/09/18 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - IR:37:1:79 [pii]
AID - 10.1007/BF02686091 [doi]
PST - ppublish
SO  - Immunol Res. 2007;37(1):79-96. doi: 10.1007/BF02686091.