PMID- 17497026
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100610
LR  - 20181113
IS  - 1110-7243 (Print)
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Linking)
VI  - 2007
IP  - 1
DP  - 2007
TI  - Thermolabile methylenetetrahydrofolate reductase C677T polymorphism and 
      homocysteine are risk factors for coronary artery disease in Moroccan population.
PG  - 80687
LID - 80687
AB  - Increased plasma total homocysteine (tHcy) levels have been shown to be a risk 
      factor for coronary artery disease (CAD). The common methylenetetrahydrofolate 
      reductase C677T (MTHFR C677T) polymorphism has been reported to be a strong 
      predictor of mild hyperhomocysteinaemia (HHcy). We assessed whether this mutation 
      was associated with increased risk of CAD and plasma levels of tHcy. We also 
      evaluated interactions between this polymorphism, mild elevated tHcy levels and 
      conventional risk factors of CAD. Method. Using PCR-RFLP analysis, we studied the 
      frequency of the C677T genotypes and its effect on CAD and on tHcy concentrations 
      in 400 subjects without and with CAD angiographically confirmed. There were 210 
      subjects with CAD and 190 subjects without CAD. Results. The frequencies of the 
      C677T genotypes were 53% (59.5% in controls versus 48.1% in cases), 34.8% (32.1 
      in controls versus 37.1 in cases), and 11.8% (8.4% in controls versus 14.8% in 
      cases), respectively, for 677CC, 677CT, and 677TT. The genotype frequencies were 
      significantly different between case and control groups (P < .05). The 677T 
      allele enhances the risk of CAD associated to HHcy (P < .01). In multivariate 
      analysis models, MTHFR C677T polymorphism effect on CAD was masked by other risk 
      factors. HHcy was only and independently influenced by MTHFR polymorphism and 
      smoking habits, and it is a strong predictor of CAD independently of conventional 
      risk factors. Conclusion. Our data suggest that HHcy is strongly and 
      independently associated to CAD risk increase; and MTHFR C677T polymorphism and 
      smoking habits were the main predictors of tHcy levels. The CAD risk increase is 
      mainly associated with mild HHcy in 677TT, whereas in 677CT and 677CC it is 
      mainly associated with the conventional risk factors.
FAU - Bennouar, Nawal
AU  - Bennouar N
AD  - National League of Cardiology, Biochemistry and Molecular Biology Laboratory, 
      Ibn-Sina Hospital, Rabat 10000, Morocco.
FAU - Allami, Abdellatif
AU  - Allami A
FAU - Azeddoug, Houssine
AU  - Azeddoug H
FAU - Bendris, Abdenbi
AU  - Bendris A
FAU - Laraqui, Abdelilah
AU  - Laraqui A
FAU - El Jaffali, Amal
AU  - El Jaffali A
FAU - El Kadiri, Nizar
AU  - El Kadiri N
FAU - Benzidia, Rachid
AU  - Benzidia R
FAU - Benomar, Anwar
AU  - Benomar A
FAU - Fellat, Seddik
AU  - Fellat S
FAU - Benomar, Mohamed
AU  - Benomar M
LA  - eng
PT  - Journal Article
DEP - 20070307
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
PMC - PMC1852902
EDAT- 2007/05/15 09:00
MHDA- 2007/05/15 09:01
PMCR- 2007/03/07
CRDT- 2007/05/15 09:00
PHST- 2006/09/21 00:00 [received]
PHST- 2006/12/20 00:00 [revised]
PHST- 2007/01/09 00:00 [accepted]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/05/15 09:01 [medline]
PHST- 2007/05/15 09:00 [entrez]
PHST- 2007/03/07 00:00 [pmc-release]
AID - 10.1155/2007/80687 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2007;2007(1):80687. doi: 10.1155/2007/80687. Epub 2007 Mar 
      7.