PMID- 17497222
OWN - NLM
STAT- MEDLINE
DCOM- 20080219
LR  - 20220321
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 53
IP  - 1
DP  - 2008 Jan
TI  - The diagnostic yield of various tests for Helicobacter pylori infection in 
      patients on acid-reducing drugs.
PG  - 95-100
AB  - The diagnostic yield of various tests for Helicobacter pylori infection in 
      patients on acid-reducing drugs, such as proton pump inhibitors (PPI) and 
      histamine-2 receptor blocker (H2RB), was compared. Seventy-four consecutive 
      patients on acid-reducing drugs were enrolled: 34 (46%) were on PPIs, 20 (27%) 
      were on H2RBs and 20 (27%) were not on medications. For those patients on PPIs, 
      RUT and histology results from antrum were negative in 28 (82%) and 17 (50%) 
      patients, respectively (OR: 4.7; 95% CI: 1.4-16.6; P = 0.004), while those from 
      the corpus were negative in was 28 (82%) and 18 (53%) patients, respectively (OR: 
      4.4, 95% CI: 1.3-15.5; P = 0.006). For patients on H2RBs, RUT and histology 
      results from the antrum were negative in 12 (60%) and six (30%) patients, 
      respectively (OR: 3.5; 95% CI: 0.8-16.1; P = 0.05), while those from the corpus 
      were negative in 12 (60%) and nine (45%) patients, respectively (OR: 1.8; 95% CI: 
      0.4-7.8; P = 0.342). For those patients on PPIs, the diagnostic yield of both RUT 
      and histology was reduced from both the antrum and corpus. In these patients, PCR 
      for H. pylori is more sensitive than RUT and histology.
FAU - Yakoob, Javed
AU  - Yakoob J
AD  - Department of Gastroenterology and Pathology, Aga Khan University Hospital, 
      Karachi, Pakistan.
FAU - Jafri, Wasim
AU  - Jafri W
FAU - Abbas, Zaigham
AU  - Abbas Z
FAU - Abid, Shahab
AU  - Abid S
FAU - Islam, Muhammad
AU  - Islam M
FAU - Ahmed, Zubair
AU  - Ahmed Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070512
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (RNA, Bacterial)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Bacterial/analysis
MH  - Biopsy
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - Gastric Mucosa/microbiology/*pathology
MH  - Gastritis/complications/*diagnosis/drug therapy
MH  - Gastroscopy/*methods
MH  - Helicobacter Infections/complications/*diagnosis/microbiology
MH  - Helicobacter pylori/genetics/immunology/isolation & purification
MH  - Histamine H2 Antagonists/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - RNA, Bacterial/analysis
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2007/05/15 09:00
MHDA- 2008/02/20 09:00
CRDT- 2007/05/15 09:00
PHST- 2006/12/07 00:00 [received]
PHST- 2007/03/16 00:00 [accepted]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2008/02/20 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - 10.1007/s10620-007-9828-y [doi]
PST - ppublish
SO  - Dig Dis Sci. 2008 Jan;53(1):95-100. doi: 10.1007/s10620-007-9828-y. Epub 2007 May 
      12.