PMID- 17497291
OWN - NLM
STAT- MEDLINE
DCOM- 20080702
LR  - 20181201
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 27
IP  - 2
DP  - 2007 Apr
TI  - Experimental research on ectopic osteogenesis of BMP2-derived peptide P24 
      combined with PLGA copolymers.
PG  - 179-82
AB  - To experimentally evaluate the ectopic osteogenetic capacity of synthesized 
      BMP2-derived peptide P24 combined with poly lactic-co-glycolic acid (PLGA), 
      Wistar rats were divided into two groups: group A, in which BMP2-derived peptide 
      P24/PLGA complex was implanted, and group B which received simple PLGA implant. 
      The complex was respectively implanted into the back muscles of rats. Samples 
      were taken the 1st, 4th, 8th, and the 12th week after the implantation. Their 
      bone formation was detected by X-ray examination, and tissue response was 
      histologically observed. Western blotting was used for the detection of the 
      expression of collagen I (Col-I) and osteopontin (OPN). There was acute 
      inflammation in the tissue around both types of implants at early stage. The 
      cartilage was found around implant areas 4 weeks after the implantation of 
      BMP2-derived peptide p24/PLGA complex, 8 weeks after the implantation, 
      osteoblasts were found, and 12 weeks after the implantation, typical trabecular 
      bone structure was observed. In group B, after 12 weeks, no osteoblasts were 
      found. It is concluded that PLGA is an ideal scaffold material for bone tissue 
      engineering. BMP2-derived peptide can start endochondral ossification and is more 
      effective in inducing ectopic osteogenesis.
FAU - Duan, Zhixia
AU  - Duan Z
AD  - Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. duanzhixia56789@126.com
FAU - Zheng, Qixin
AU  - Zheng Q
FAU - Guo, Xiaodong
AU  - Guo X
FAU - Yuan, Quan
AU  - Yuan Q
FAU - Chen, Shunguang
AU  - Chen S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bmp2 protein, rat)
RN  - 0 (Bone Morphogenetic Protein 2)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Peptides)
RN  - 0 (Transforming Growth Factor beta)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry
MH  - Bone Morphogenetic Protein 2
MH  - Bone Morphogenetic Proteins/chemistry/*pharmacology
MH  - Guided Tissue Regeneration
MH  - Implants, Experimental
MH  - Lactic Acid/chemistry/*pharmacology
MH  - Osteogenesis/*drug effects
MH  - Peptides/chemistry/pharmacology
MH  - Polyglycolic Acid/chemistry/*pharmacology
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Tissue Engineering/*methods
MH  - Transforming Growth Factor beta/chemistry/*pharmacology
EDAT- 2007/05/15 09:00
MHDA- 2008/07/03 09:00
CRDT- 2007/05/15 09:00
PHST- 2006/08/09 00:00 [received]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2008/07/03 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - 10.1007/s11596-007-0219-6 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2007 Apr;27(2):179-82. doi: 
      10.1007/s11596-007-0219-6.