PMID- 17498061
OWN - NLM
STAT- MEDLINE
DCOM- 20070716
LR  - 20070514
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 217
DP  - 2007 Jun
TI  - The mast cell IgG receptors and their roles in tissue inflammation.
PG  - 206-21
AB  - Mast cells are effector cells of the innate immune system, but because they 
      express Fc receptors (FcRs), they can be engaged in adaptive immunity by 
      antibodies. Mast cell FcRs include immunoglobulin E (IgE) and IgG receptors and, 
      among these, activating and inhibitory receptors. The engagement of mast cell IgG 
      receptors by immune complexes may or may not trigger cell activation, depending 
      on the type of mast cell. The coengagement of IgG and IgE receptors results in 
      inhibition of mast cell activation. The Src homology-2 domain-containing inositol 
      5-phosphatase-1 is a major effector of negative regulation. Biological responses 
      of mast cells depend on the balance between positive and negative signals that 
      are generated in FcR complexes. The contribution of human mast cell IgG receptors 
      in allergies remains to be clarified. Increasing evidence indicates that mast 
      cells play critical roles in IgG-dependent tissue-specific autoimmune diseases. 
      Convincing evidence was obtained in murine models of multiple sclerosis, 
      rheumatoid arthritis, bullous pemphigoid, and glomerulonephritis. In these 
      models, the intensity of lesions depended on the relative engagement of 
      activating and inhibitory IgG receptors. In vitro models of mature 
      tissue-specific murine mast cells are needed to investigate the roles of mast 
      cells in these diseases. One such model unraveled unique 
      differentiation/maturation-dependent biological responses of serosal-type mast 
      cells.
FAU - Malbec, Odile
AU  - Malbec O
AD  - Unite d'Allergologie Moleculaire et Cellulaire, Departement d'Immunologie, 
      Institut Pasteur, Paris, France.
FAU - Daeron, Marc
AU  - Daeron M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Animals
MH  - Autoantibodies/immunology
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immunoglobulin G/immunology
MH  - Inflammation/*immunology
MH  - Mast Cells/*immunology
MH  - Mice
MH  - Receptors, IgE/immunology
MH  - Receptors, IgG/*immunology
RF  - 170
EDAT- 2007/05/15 09:00
MHDA- 2007/07/17 09:00
CRDT- 2007/05/15 09:00
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/07/17 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - IMR510 [pii]
AID - 10.1111/j.1600-065X.2007.00510.x [doi]
PST - ppublish
SO  - Immunol Rev. 2007 Jun;217:206-21. doi: 10.1111/j.1600-065X.2007.00510.x.