PMID- 17498063
OWN - NLM
STAT- MEDLINE
DCOM- 20070716
LR  - 20161124
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 217
DP  - 2007 Jun
TI  - Regulation of the mast cell response to the type 1 Fc epsilon receptor.
PG  - 231-54
AB  - The type I Fc epsilon receptor (Fc epsilon RI) is one of the better understood 
      members of its class and is central to the immunological activation of mast cells 
      and basophils, the key players in immunoglobulin E (IgE)-dependent immediate 
      hypersensitivity. This review provides background information on several distinct 
      regulatory mechanisms controlling this receptor's stimulus-response coupling 
      network. First, we review the current understanding of this network's operation, 
      and then we focus on the inhibitory regulatory mechanisms. In particular, we 
      discuss the different known cytosolic molecules (e.g. kinases, phosphatases, and 
      adapters) as well as cell membrane proteins involved in negatively regulating the 
      Fc epsilon RI-induced secretory responses. Knowledge of this field is developing 
      at a fast rate, as new proteins endowed with regulatory functions are still being 
      discovered. Our understanding of the complex networks by which these proteins 
      exert regulation is limited. Although the scope of this review does not include 
      addressing several important biochemical and biophysical aspects of the 
      regulatory mechanisms, it does provide general insights into a central field in 
      immunology.
FAU - Abramson, Jakub
AU  - Abramson J
AD  - Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
FAU - Pecht, Israel
AU  - Pecht I
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, Immunologic)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/metabolism
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cytosol/enzymology/*metabolism
MH  - Humans
MH  - Mast Cells/enzymology/*immunology
MH  - Molecular Sequence Data
MH  - Phosphoric Monoester Hydrolases/immunology
MH  - Protein Kinases/metabolism
MH  - Receptors, IgE/agonists/*immunology
MH  - Receptors, Immunologic/immunology
MH  - Ubiquitin-Protein Ligases/metabolism
RF  - 237
EDAT- 2007/05/15 09:00
MHDA- 2007/07/17 09:00
CRDT- 2007/05/15 09:00
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/07/17 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - IMR518 [pii]
AID - 10.1111/j.1600-065X.2007.00518.x [doi]
PST - ppublish
SO  - Immunol Rev. 2007 Jun;217:231-54. doi: 10.1111/j.1600-065X.2007.00518.x.