PMID- 17498269
OWN - NLM
STAT- MEDLINE
DCOM- 20070627
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 6
DP  - 2007 Jun
TI  - HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek 
      population.
PG  - 592-6
AB  - It is well established that genetic factors play an important role in the 
      pathogenesis of osteoporosis, a common condition characterized by reduced bone 
      mass and increased fracture risk. The major histocompatibility complex in humans, 
      known as human leukocyte antigen (HLA) region, is the most polymorphic human 
      genetic system and it is known as a cluster of genetic markers, associated with 
      several diseases. In order to evaluate the contribution of HLA alleles in bone 
      mass loss, polymorphisms in the HLA class I (-A, -B and -Cw) and class II (-DR 
      and -DQ) antigens were studied in 126 postmenopausal women of Greek origin. It 
      was found that HLA-B7 (P= 0.069), -DR15 (P= 0.019) and -DQ6 (P= 0.026) were 
      associated with a lower bone mineral density measured at the forearm. This study 
      shows a significant association between HLA alleles and bone mass loss in the 
      population studied.
FAU - Douroudis, K
AU  - Douroudis K
AD  - Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, 
      Greece. drkmb@email.com
FAU - Tarassi, K
AU  - Tarassi K
FAU - Athanassiades, T
AU  - Athanassiades T
FAU - Giannakopoulos, F
AU  - Giannakopoulos F
FAU - Kominakis, A
AU  - Kominakis A
FAU - Thalassinos, N
AU  - Thalassinos N
FAU - Papasteriades, Ch
AU  - Papasteriades Ch
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ6 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR15 antigen)
SB  - IM
MH  - Alleles
MH  - Bone Density/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Greece
MH  - HLA Antigens/*genetics
MH  - HLA-B7 Antigen/genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DR Serological Subtypes
MH  - Humans
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/*genetics/*immunology/physiopathology
MH  - Risk Factors
EDAT- 2007/05/15 09:00
MHDA- 2007/06/28 09:00
CRDT- 2007/05/15 09:00
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/06/28 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - TAN833 [pii]
AID - 10.1111/j.1399-0039.2007.00833.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Jun;69(6):592-6. doi: 10.1111/j.1399-0039.2007.00833.x.