PMID- 17498558
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20131121
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 175
IP  - 1
DP  - 2007 May
TI  - A case of chronic myeloproliferative syndrome followed by precursor T-cell acute 
      lymphoblastic leukemia.
PG  - 52-6
AB  - Interlineage switch from myeloid to lymphatic malignancies is a rare phenomenon. 
      Progression from a BCR-ABL negative chronic myeloproliferative disorder (CMPD) to 
      acute lymphoblastic leukemia (ALL) has been reported in very few cases. We 
      describe the case of a 62-year-old man who developed precursor T-cell (pre-T) ALL 
      18 months after the diagnosis of an unclassifiable chronic myeloproliferative 
      syndrome (CMPD, U), which had been treated with hydroxyurea (HU) over 12 months. 
      The transformation from CMPD to pre-T-ALL was accompanied by clonal evolution 
      from normal to a high hyperdiploid karyotype with an i(17q): 
      52,XY,+X,+2,+13,+14,+15,i(17)(q10),+19. Diverse pathways should be considered in 
      this transformation process: although therapeutic induction of ALL is extremely 
      rare and no MLL/11q23 rearrangement was detected by chromosome banding analyses 
      and interphase fluorescence in situ hybridization (FISH), T-lineage ALL might 
      have been caused by HU therapy for the CMPD. Chance coincidence of both disorders 
      seems improbable, given the short interval from the diagnosis of the CMPD to the 
      development of the pre-T-ALL, but nonetheless must be considered. A third 
      explanation might be provided by a spontaneous interlineage switch, which would 
      give further support to the theory that the CMPDs are disorders of a pluripotent 
      stem cell. Interlineage switch might result from an aberrant differentiation of 
      the malignant clone or from selection within a mixed population.
FAU - Bacher, Ulrike
AU  - Bacher U
AD  - Bone Marrow Transplant Unit, University Hospital of Hamburg-Eppendorf, 
      Martinistr. 52, 20246 Hamburg, Germany. ubacher@uke.uni-hamburg.de
FAU - Haferlach, Torsten
AU  - Haferlach T
FAU - Kern, Wolfgang
AU  - Kern W
FAU - Harich, Hans-Detlev
AU  - Harich HD
FAU - Schnittger, Susanne
AU  - Schnittger S
FAU - Haferlach, Claudia
AU  - Haferlach C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Nucleic Acid Synthesis Inhibitors)
RN  - X6Q56QN5QC (Hydroxyurea)
SB  - IM
MH  - Cell Transformation, Neoplastic/genetics
MH  - Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosome Painting
MH  - Disease Progression
MH  - Humans
MH  - Hydroxyurea/therapeutic use
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myeloproliferative Disorders/drug therapy/genetics/*pathology
MH  - Nucleic Acid Synthesis Inhibitors/therapeutic use
MH  - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics/*pathology
MH  - Syndrome
EDAT- 2007/05/15 09:00
MHDA- 2007/06/27 09:00
CRDT- 2007/05/15 09:00
PHST- 2006/10/10 00:00 [received]
PHST- 2006/12/15 00:00 [revised]
PHST- 2006/12/29 00:00 [accepted]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - S0165-4608(07)00004-0 [pii]
AID - 10.1016/j.cancergencyto.2006.12.007 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 May;175(1):52-6. doi: 
      10.1016/j.cancergencyto.2006.12.007.