PMID- 17498563
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20161124
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 175
IP  - 1
DP  - 2007 May
TI  - A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia 
      and Burkitt lymphoma.
PG  - 73-6
AB  - In three patients with acute lymphoblastic leukemia (ALL) and in another with 
      Burkitt lymphoma (BL), conventional cytogenetics and fluorescence in situ 
      hybridization (FISH), applied singly or in combination, showed 1q duplication in 
      two cases of ALL with hyperdiploid karyotypes, 1q duplication resulting from an 
      unbalanced translocation in a third case of ALL, and inv dup(1)(q) in a patient 
      with BL. Centromeric or telomeric breakpoints and extension of the 1q duplicons 
      varied in each case. FISH defined a minimal, common duplicated region of 93kb at 
      band 1q21.2 corresponding to clone RP11-212K13. In this region three putative 
      oncogenes or tumor suppressor genes have been mapped: SF3B4 (splicing factor 3b, 
      subunit 4), OTUD7B (OTU domain containing 7B), and MTMR11 (myotubularin related 
      protein 11). For the first time, a minimal common 1q21.2 duplicated sequence has 
      been identified in lymphoid malignancies in a region where putative oncogenes or 
      suppressor genes have been mapped. This finding elucidates the genomic background 
      of ALL and BL with 1q duplication and provides the basis for molecular studies 
      investigating which genes are involved in leukemogenesis or disease progression 
      in these cases.
FAU - La Starza, Roberta
AU  - La Starza R
AD  - Department of Hematology, University of Perugia, IBiT Foundation, Fondazione 
      IRCCS Biotecnologie nel Trapianto, via Brunamonti 51, 06122 Perugia, Italy.
FAU - Crescenzi, Barbara
AU  - Crescenzi B
FAU - Pierini, Valentina
AU  - Pierini V
FAU - Romoli, Silvia
AU  - Romoli S
FAU - Gorello, Paolo
AU  - Gorello P
FAU - Brandimarte, Lucia
AU  - Brandimarte L
FAU - Matteucci, Caterina
AU  - Matteucci C
FAU - Kropp, Maria Grazia
AU  - Kropp MG
FAU - Barba, Gianluca
AU  - Barba G
FAU - Martelli, Massimo Fabrizio
AU  - Martelli MF
FAU - Mecucci, Cristina
AU  - Mecucci C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (RNA Splicing Factors)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (SF3B4 protein, human)
SB  - IM
MH  - Burkitt Lymphoma/*genetics
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Female
MH  - *Gene Duplication
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - RNA Splicing Factors
MH  - RNA-Binding Proteins/genetics
EDAT- 2007/05/15 09:00
MHDA- 2007/06/27 09:00
CRDT- 2007/05/15 09:00
PHST- 2006/10/16 00:00 [received]
PHST- 2007/01/17 00:00 [revised]
PHST- 2007/01/22 00:00 [accepted]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - S0165-4608(07)00073-8 [pii]
AID - 10.1016/j.cancergencyto.2007.01.011 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 May;175(1):73-6. doi: 
      10.1016/j.cancergencyto.2007.01.011.