PMID- 17498687
OWN - NLM
STAT- MEDLINE
DCOM- 20070919
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 566
IP  - 1-3
DP  - 2007 Jul 2
TI  - Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation 
      in the adult mouse dentate gyrus.
PG  - 120-3
AB  - We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) 
      treatment on cell proliferation in the adult dentate gyrus. Mice were orally 
      treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing 
      cells, mice were given 5-bromo-2'-deoxyuridine (BrdU) for 4 days from the day 
      after the last administration of MDMA, and their brains were examined 24 h later. 
      MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in 
      the male and female dentate gyrus. Our results suggest that chronic exposure to 
      MDMA suppresses cell proliferation in the dentate gyrus.
FAU - Cho, Kyung-Ok
AU  - Cho KO
AD  - Department of Pharmacology, College of Medicine, The Catholic University of 
      Korea, 137-701, Seoul, South Korea.
FAU - Kim, Seul-Ki
AU  - Kim SK
FAU - Rhee, Gyu Seek
AU  - Rhee GS
FAU - Kwack, Seung Jun
AU  - Kwack SJ
FAU - Cho, Dae Hyun
AU  - Cho DH
FAU - Sung, Ki-Wug
AU  - Sung KW
FAU - Kim, Seong Yun
AU  - Kim SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070420
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Hallucinogens)
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/drug effects
MH  - Dentate Gyrus/cytology/*drug effects
MH  - Female
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Serotonin Agents/pharmacology
EDAT- 2007/05/15 09:00
MHDA- 2007/09/20 09:00
CRDT- 2007/05/15 09:00
PHST- 2007/01/25 00:00 [received]
PHST- 2007/03/28 00:00 [revised]
PHST- 2007/04/01 00:00 [accepted]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/09/20 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - S0014-2999(07)00432-3 [pii]
AID - 10.1016/j.ejphar.2007.04.008 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2007 Jul 2;566(1-3):120-3. doi: 10.1016/j.ejphar.2007.04.008. 
      Epub 2007 Apr 20.