PMID- 17498710
OWN - NLM
STAT- MEDLINE
DCOM- 20071108
LR  - 20131121
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 88
IP  - 4
DP  - 2007 Oct
TI  - Erectile dysfunction: does insulin resistance play a part?
PG  - 771-8
AB  - OBJECTIVE: To review MEDLINE literature for correlations between insulin 
      resistance and erectile dysfunction (ED). DESIGN: MEDLINE literature review (1966 
      to present). SETTING: Academic medical center. PATIENT(S): None. INTERVENTION(S): 
      None. MAIN OUTCOME MEASURE(S): None. RESULT(S): Erectile dysfunction affects more 
      than half of men over the age of 40. Fortunately, most men with ED can be 
      successfully treated with phosphodiesterase 5A (PDE-5) inhibitors, which 
      up-regulate the vasodilatory effects of nitric oxide (NO). Insulin resistance 
      affects 25% of U.S. adults and increases to a 60% occurrence in individuals who 
      are overweight. Endothelial dysfunction, which is associated with insulin 
      resistance states, can cause disturbances in the subcellular signaling pathways 
      required for NO production. Because endothelial production of NO and insulin 
      sensitivity are positively related in healthy humans, the relationships among 
      insulin resistance, NO, and ED are the target of this review of MEDLINE 
      literature. CONCLUSION(S): Insulin resistance states are characterized by 
      defective vascular NO production and impaired insulin-induced vasodilation, both 
      of which are likely to cause ED. Diagnosing and treating insulin resistance 
      should be part of the initial management plan for ED. Future studies concerning 
      the cause and effect relationship of insulin resistance and ED should be 
      implemented.
FAU - Trussell, J C
AU  - Trussell JC
AD  - Division of Urology, Penn State Milton S. Hershey Medical Center and Penn State 
      College of Medicine, Hershey, PA 17033-0850, USA. jtrussell@psu.edu
FAU - Legro, Richard S
AU  - Legro RS
LA  - eng
GR  - K24 HD01476/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20070511
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Insulin)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Adrenergic beta-Antagonists/therapeutic use
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Erectile Dysfunction/drug therapy/*etiology
MH  - Gonadal Steroid Hormones/physiology
MH  - Humans
MH  - Insulin/physiology
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/physiology
MH  - Nitric Oxide Synthase/antagonists & inhibitors/physiology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Proto-Oncogene Proteins c-akt/physiology
RF  - 72
EDAT- 2007/05/15 09:00
MHDA- 2007/11/09 09:00
CRDT- 2007/05/15 09:00
PHST- 2006/10/19 00:00 [received]
PHST- 2007/01/17 00:00 [revised]
PHST- 2007/01/17 00:00 [accepted]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/11/09 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - S0015-0282(07)00274-9 [pii]
AID - 10.1016/j.fertnstert.2007.01.116 [doi]
PST - ppublish
SO  - Fertil Steril. 2007 Oct;88(4):771-8. doi: 10.1016/j.fertnstert.2007.01.116. Epub 
      2007 May 11.