PMID- 17499233
OWN - NLM
STAT- MEDLINE
DCOM- 20070817
LR  - 20221207
IS  - 0009-9120 (Print)
IS  - 0009-9120 (Linking)
VI  - 40
IP  - 11
DP  - 2007 Jul
TI  - Association of serum levels of glycated albumin, C-reactive protein and tumor 
      necrosis factor-alpha with the severity of coronary artery disease and renal 
      impairment in patients with type 2 diabetes mellitus.
PG  - 810-6
AB  - OBJECTIVES: This study aimed to determine whether elevated serum levels of 
      glycated albumin, high-sensitivity C-reactive protein (hsCRP) and tumor necrosis 
      factor (TNF)-alpha were related to an increased risk for coronary artery disease 
      (CAD) and renal insufficiency in patients with type 2 diabetes mellitus (T2DM). 
      DESIGN AND METHODS: Serum levels of glycated albumin, hsCRP, TNF-alpha and blood 
      glycosylated hemoglobin A1c (HbA1c) were measured in 317 consecutive patients 
      with T2DM and 309 normal controls. Patients with T2DM were grouped based upon 
      coronary angiographic findings (Group I: 151 patients with normal coronary 
      arteries; Group II: 166 patients with significant coronary stenosis [>70% luminal 
      diameter narrowing]) and renal functional status evaluated by estimated 
      creatinine clearance (CrCl) (normal renal function group: 187 patients with CrCl 
      >90 mL/min; mild renal insufficiency group: 103 patients with CrCl 60-90 mL/min; 
      moderate renal insufficiency group: 27 patients with CrCl 30-60 mL/min). 
      Multivariate analysis was performed to determine independent risk factors for CAD 
      and renal insufficiency in patients with T2DM. RESULTS: Serum levels of glycated 
      albumin, hsCRP and TNF-alpha were significantly higher in Group II than in 
      controls (P<0.01) and Group I (P<0.01). A significant difference was found in 
      glycated albumin, hsCRP and TNF-alpha levels among diabetic patients with mild, 
      moderate renal insufficiency and normal renal function (P<0.05). These 
      biochemical measurements correlated significantly with number of diseased 
      coronary vessels (P<0.01) and status of renal function (P<0.05). No difference 
      existed in HbA1c levels between Group II and Group I, and among patients with 
      various CrCL stages. Multivariate analysis revealed that male gender, old age and 
      serum levels of glycated albumin, hsCRP, TNF-alpha and lipoprotein (a) were 
      independent risk factors for CAD, and older age, hypertension and glycated 
      albumin were for CrCl <60 mL/min in diabetes. CONCLUSIONS: Increased serum levels 
      of glycated albumin, hsCRP and TNF-alpha are associated with the presence and 
      severity of CAD and renal impairment in patients with T2DM.
FAU - Lu, Lin
AU  - Lu L
AD  - Department of Cardiology, Rui Jin Hospital, Jiaotong University School of 
      Medicine, Shanghai, PR China.
FAU - Pu, Li Jin
AU  - Pu LJ
FAU - Xu, Xue Wei
AU  - Xu XW
FAU - Zhang, Qi
AU  - Zhang Q
FAU - Zhang, Rui Yan
AU  - Zhang RY
FAU - Zhang, Jian Sheng
AU  - Zhang JS
FAU - Hu, Jian
AU  - Hu J
FAU - Yang, Zheng Kun
AU  - Yang ZK
FAU - Lu, An Kang
AU  - Lu AK
FAU - Ding, Feng Hua
AU  - Ding FH
FAU - Shen, Jie
AU  - Shen J
FAU - Chen, Qiu Jin
AU  - Chen QJ
FAU - Lou, Sheng
AU  - Lou S
FAU - Fang, Dan Hong
AU  - Fang DH
FAU - Shen, Wei Feng
AU  - Shen WF
LA  - eng
PT  - Journal Article
DEP - 20070419
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Serum Albumin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/*metabolism
MH  - Coronary Artery Disease/*blood/pathology
MH  - Diabetes Mellitus, Type 2/*blood/pathology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Kidney Diseases/*blood/pathology
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Risk Factors
MH  - Serum Albumin/*metabolism
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Glycated Serum Albumin
EDAT- 2007/05/15 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/05/15 09:00
PHST- 2007/01/31 00:00 [received]
PHST- 2007/03/17 00:00 [revised]
PHST- 2007/03/27 00:00 [accepted]
PHST- 2007/05/15 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/05/15 09:00 [entrez]
AID - S0009-9120(07)00163-4 [pii]
AID - 10.1016/j.clinbiochem.2007.03.022 [doi]
PST - ppublish
SO  - Clin Biochem. 2007 Jul;40(11):810-6. doi: 10.1016/j.clinbiochem.2007.03.022. Epub 
      2007 Apr 19.