PMID- 17500207
OWN - NLM
STAT- MEDLINE
DCOM- 20070709
LR  - 20161020
IS  - 0869-6047 (Print)
IS  - 0869-6047 (Linking)
IP  - 3
DP  - 2007
TI  - [The molecular-genetic aspects of differentiation of schizoaffective psychosis 
      and attack-like progressive schizophrenia].
PG  - 3-8
AB  - To clarify nosologic differences between schizoaffective psychosis (SAP) and 
      attack-like progressive schizophrenia at molecular-genetic level, the genetic 
      polymorphism of serotonin receptor type 2A (5HTR2A), serotonin transporter 
      (5-HTTLRP), and brain-derived neurotrophic factor (BDNF) was studied in 563 
      patients with schizophrenia (mean age 37.7+/-14.4 years, age at disease onset 
      26.7+/-11.4 years), and 171 patients with SAP (mean age 30.7+/-11.6 years, age at 
      disease onset 24.9+/-8.5 years). The control group consisted of 536 
      psychiatrically well subjects. Clinical symptoms and personal features were 
      evaluated as well. By comparison with schizophrenic patients, those with SAP were 
      featured by subtle negative symptoms and personality changes that supported the 
      evidence that SAP is a disorder with a favorable outcome. Molecular-genetic 
      studies revealed higher frequencies of S allele and SS genotype (5-HTTLPR 
      polymorphism), which are thought to be associated with depression and depressive 
      symptoms, and higher frequency of BDNF genotypes, containing Met allele, in 
      combination with 5-HTTLRP genotypes containing L allele, in patients with SAP as 
      compared to the schizophrenic group. C allele and CC genotype (T102C 5-HTR2A 
      polymorphism) frequencies were higher in both groups of patients vs. controls. In 
      conclusion, the results confirm the concept considering SAP an independent 
      nosologic category.
FAU - Golimbet, V E
AU  - Golimbet VE
FAU - Abramova, L I
AU  - Abramova LI
FAU - Kaleda, V G
AU  - Kaleda VG
FAU - Alfimova, M V
AU  - Alfimova MV
FAU - Korovaitseva, G I
AU  - Korovaitseva GI
FAU - Lavrushina, O M
AU  - Lavrushina OM
FAU - Barkhatova, A N
AU  - Barkhatova AN
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Vestn Ross Akad Med Nauk
JT  - Vestnik Rossiiskoi akademii meditsinskikh nauk
JID - 9215641
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Diagnosis, Differential
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/diagnosis
MH  - Receptor, Serotonin, 5-HT2A/genetics
MH  - Schizoid Personality Disorder/diagnosis
MH  - Schizophrenia/diagnosis/*genetics
MH  - Serotonin Plasma Membrane Transport Proteins/genetics
MH  - Time Factors
EDAT- 2007/05/16 09:00
MHDA- 2007/07/10 09:00
CRDT- 2007/05/16 09:00
PHST- 2007/05/16 09:00 [pubmed]
PHST- 2007/07/10 09:00 [medline]
PHST- 2007/05/16 09:00 [entrez]
PST - ppublish
SO  - Vestn Ross Akad Med Nauk. 2007;(3):3-8.