PMID- 17502112
OWN - NLM
STAT- MEDLINE
DCOM- 20071019
LR  - 20091119
IS  - 0016-6480 (Print)
IS  - 0016-6480 (Linking)
VI  - 153
IP  - 1-3
DP  - 2007 Aug-Sep
TI  - Expression and physiological regulation of BDNF receptors in the neuroendocrine 
      melanotrope cell of Xenopus laevis.
PG  - 176-81
AB  - Brain-derived neurotrophic factor (BDNF) and alpha-melanophore-stimulating 
      hormone (alpha-MSH) are co-sequestered in secretory granules in melanotrope cells 
      of the pituitary pars intermedia of the amphibian Xenopus laevis. alpha-MSH is 
      responsible for pigment dispersion in dermal melanophores during the process of 
      black-background adaptation. BDNF-production in melanotrope cells is increased by 
      placing animals on a black background, and BDNF acts as an autocrine stimulatory 
      factor on the melanotrope cells. However, the repertoire of possible neurotrophin 
      receptors of the melanotrope is unknown. In this study we have established the 
      expression of full length TrkB (TrkB.FL), truncated TrkB (TrkB.T) and p75(NTR) 
      receptors in the Xenopus neurointermediate lobe by RT-PCR. In situ hybridization 
      reveals the presence of TrkB.FL mRNA and p75(NTR) mRNA in melanotrope cells. 
      Quantitative RT-PCR shows that in animals on a black background the amounts of 
      TrkB.T and p75(NTR) mRNA are about three times higher than in white 
      background-adapted animals. We suggest that the amount of p75(NTR) sets the 
      sensitivity of the melanotrope cells for the stimulatory action of BDNF during 
      physiological adaptation to background light intensity.
FAU - Kidane, Adhanet H
AU  - Kidane AH
AD  - Department of Cellular Animal Physiology, Integrative Physiology, EURON European 
      Graduate School of Neuroscience, Radboud University Nijmegen, Toernooiveld 1, 
      6525 ED Nijmegen, The Netherlands.
FAU - van Dooren, Sander H J
AU  - van Dooren SH
FAU - Roubos, Eric W
AU  - Roubos EW
FAU - Jenks, Bruce G
AU  - Jenks BG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070411
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 0 (Isoenzymes)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
CIN - Gen Comp Endocrinol. 2007 Aug-Sep;153(1-3):97. PMID: 17666204
MH  - Adaptation, Biological/genetics
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Gene Expression Regulation
MH  - Isoenzymes/genetics/metabolism
MH  - Melanotrophs/*metabolism/*physiology
MH  - Molecular Sequence Data
MH  - Receptor, Nerve Growth Factor/genetics/metabolism
MH  - Receptor, trkB/*genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Skin Physiological Phenomena/genetics
MH  - Skin Pigmentation/genetics
MH  - Xenopus laevis/*genetics
EDAT- 2007/05/16 09:00
MHDA- 2007/10/20 09:00
CRDT- 2007/05/16 09:00
PHST- 2006/09/29 00:00 [received]
PHST- 2007/03/28 00:00 [revised]
PHST- 2007/04/01 00:00 [accepted]
PHST- 2007/05/16 09:00 [pubmed]
PHST- 2007/10/20 09:00 [medline]
PHST- 2007/05/16 09:00 [entrez]
AID - S0016-6480(07)00139-6 [pii]
AID - 10.1016/j.ygcen.2007.04.001 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 2007 Aug-Sep;153(1-3):176-81. doi: 
      10.1016/j.ygcen.2007.04.001. Epub 2007 Apr 11.