PMID- 17503392
OWN - NLM
STAT- MEDLINE
DCOM- 20070613
LR  - 20070515
IS  - 0919-9454 (Print)
IS  - 0919-9454 (Linking)
VI  - 17
IP  - 2
DP  - 2006
TI  - PepSOM: an algorithm for peptide identification by tandem mass spectrometry based 
      on SOM.
PG  - 194-205
AB  - Peptide identification by tandem mass spectrometry is both an important and 
      challenging problem in proteomics. At present, huge amount of spectrum data are 
      generated by high throughput mass spectrometers at a very fast pace, but 
      algorithms to analyze these spectra are either too slow, not accurate enough, or 
      only gives partial sequences or sequence tags. In this paper, we emphasize on the 
      balance between identification completeness and efficiency with reasonable 
      accuracy for peptide identification by tandem mass spectrum. Our method works by 
      converting spectra to vectors in high-dimensional space, and subsequently use 
      self-organizing map (SOM) and multi-point range query (MPRQ) algorithm as a 
      coarse filter reduce the number of candidates to achieve efficient and accurate 
      database search. Experiments show that our algorithm is both fast and accurate in 
      peptide identification.
FAU - Ning, Kang
AU  - Ning K
AD  - Department of Computer Science, School of Computing, National University of 
      Singapore, 3 Science Drive 2, 117543, Singapore. ningkang@comp.nus.edu.sg
FAU - Ng, Hoong Kee
AU  - Ng HK
FAU - Leong, Hon Wai
AU  - Leong HW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Genome Inform
JT  - Genome informatics. International Conference on Genome Informatics
JID - 101280573
RN  - 0 (Peptides)
SB  - IM
MH  - *Algorithms
MH  - Computational Biology
MH  - Databases, Protein
MH  - Microcomputers
MH  - Models, Biological
MH  - *Peptide Mapping
MH  - Peptides/*analysis/chemistry
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Sequence Analysis, Protein
MH  - Software
MH  - Tandem Mass Spectrometry/*methods
MH  - Time Factors
EDAT- 2007/05/16 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/05/16 09:00
PHST- 2007/05/16 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/05/16 09:00 [entrez]
AID - 172194 [pii]
PST - ppublish
SO  - Genome Inform. 2006;17(2):194-205.