PMID- 17504212
OWN - NLM
STAT- MEDLINE
DCOM- 20070706
LR  - 20220317
IS  - 1567-2026 (Print)
IS  - 1567-2026 (Linking)
VI  - 4
IP  - 2
DP  - 2007 May
TI  - The role of neurotrophins in axonal growth, guidance, and regeneration.
PG  - 143-51
AB  - Neurotrophins are proteins that regulate neuronal survival, axonal growth, 
      synaptic plasticity and neurotransmission. They are members of the neurotrophic 
      factors family and include factors such as the nerve growth factor (NGF), the 
      brain derived neurotrophic factor (BDNF), the neurotrophin-3 (NT-3), and the 
      neurotrophin-4/5 (NT-4/5). These molecules bind to two types of receptors: i) 
      tyrosine kinase receptors (TrkA, TrkB, TrkC) and ii) a common neurotrophin 
      receptor (p75NTR). The two receptor types can either suppress or enhance each 
      other's actions. Neurotrophins have a multifunctional role both in the central 
      and peripheral nervous system. They have been suggested as axonal guidance 
      molecules during the growth and regeneration of nerves. It has also been proven 
      that they stimulate axonal growth by mediating the polymerization and 
      accumulation of F-actin in growth cones and axon shafts. Neurotrophins, as other 
      neurotrophic factors, have been shown that they reduce neuronal injury by 
      exposure to excitotoxins, glucose deprivation, or ischemia. Furthermore, the 
      nerve regeneration promoting effect of these growth factors is well documented 
      for many different models of central or peripheral nervous system injury. Several 
      studies have shown that exogenous administration of these factors has protective 
      properties for injured neurons and stimulates axonal regeneration. Based on these 
      properties, these molecules may be used as therapeutic agents for treating 
      degenerative diseases and traumatic injuries of both the central and peripheral 
      nervous system.
FAU - Lykissas, Marios G
AU  - Lykissas MG
AD  - Department of Orthopaedics, Ioannina University Medical School, Ioannina, Greece.
FAU - Batistatou, Anna K
AU  - Batistatou AK
FAU - Charalabopoulos, Konstantinos A
AU  - Charalabopoulos KA
FAU - Beris, Alexandros E
AU  - Beris AE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Axons/*drug effects
MH  - Cell Growth Processes/*drug effects/physiology
MH  - Humans
MH  - Nerve Growth Factors/*pharmacology/*physiology
MH  - Nerve Regeneration/*drug effects/physiology
MH  - Receptors, Nerve Growth Factor/physiology
RF  - 107
EDAT- 2007/05/17 09:00
MHDA- 2007/07/07 09:00
CRDT- 2007/05/17 09:00
PHST- 2007/05/17 09:00 [pubmed]
PHST- 2007/07/07 09:00 [medline]
PHST- 2007/05/17 09:00 [entrez]
AID - 10.2174/156720207780637216 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2007 May;4(2):143-51. doi: 10.2174/156720207780637216.