PMID- 17504510
OWN - NLM
STAT- MEDLINE
DCOM- 20070730
LR  - 20070516
IS  - 1744-3121 (Print)
IS  - 1744-3121 (Linking)
VI  - 34
IP  - 3
DP  - 2007 Jun
TI  - Molecular diversity of HLA-A, -B and -C alleles in a North Indian population as 
      determined by PCR-SSOP.
PG  - 201-8
AB  - We have used molecular methods to determine the frequencies of human leukocyte 
      antigen (HLA)-A, -B and -C alleles in normal, healthy, unrelated individuals from 
      North India using polymerase chain reaction and hybridization with 
      sequence-specific oligonucleotide probes as there is no comprehensive report 
      showing molecular diversity of all the class-I alleles present in North Indians. 
      A*0101, A*0206, A*0301, A*1101, A*6801, A*2401 and A*3101 were the most prevalent 
      alleles of the A locus with 91.11% of the samples showing heterozygosity. At the 
      HLA-B locus a total of 47 B locus alleles were observed and the only allele found 
      with an allele frequency of 15% was B*5801. Other frequent B-locus alleles 
      observed were B*5101, B*3503 and B*4006 with relatively less frequent alleles 
      like B*5201, B*3501, B*0702, B*4403, B*5701, B*1801 and B*5501. Of the samples 
      studied 92.31% were heterozygous for B-locus alleles. Cw*0602 and Cw*0401 were 
      the most frequent C-locus alleles. Other frequent C-locus alleles were Cw*0102, 
      Cw*0302, Cw*0701, Cw*0702, Cw*1202, Cw*1203, Cw*1502 and Cw*1503. HLA alleles 
      common in Africans like B*5801, A*68012, B*5301, B*44032, B*4006 and Cw*1701 were 
      observed in the North Indians besides oriental alleles like B*1301, B*1502 and 
      B*4001 confirming that the genetic make-up of North Indians is Caucasoid with 
      elements of Mongoloid and Negrito races. Some new/rare alleles like B*1802, 
      described as a new allele from Thailand and B*8101, described earlier in a Bubi 
      population were also observed although with low frequencies, showing the 
      diversity of HLA class-I alleles present in the North Indians.
FAU - Rani, R
AU  - Rani R
AD  - Neuroimmunology Laboratory, National Institute of Immunology, New Delhi, India. 
      rajni@nii.res.in
FAU - Marcos, C
AU  - Marcos C
FAU - Lazaro, A M
AU  - Lazaro AM
FAU - Zhang, Y
AU  - Zhang Y
FAU - Stastny, P
AU  - Stastny P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - India
MH  - Phylogeny
MH  - Polymerase Chain Reaction
EDAT- 2007/05/17 09:00
MHDA- 2007/07/31 09:00
CRDT- 2007/05/17 09:00
PHST- 2007/05/17 09:00 [pubmed]
PHST- 2007/07/31 09:00 [medline]
PHST- 2007/05/17 09:00 [entrez]
AID - EJI677 [pii]
AID - 10.1111/j.1744-313X.2007.00677.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2007 Jun;34(3):201-8. doi: 10.1111/j.1744-313X.2007.00677.x.