PMID- 17505177
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20101118
IS  - 0002-9629 (Print)
IS  - 0002-9629 (Linking)
VI  - 333
IP  - 5
DP  - 2007 May
TI  - Monoclonal gammopathy presenting as recurrent nephrotic syndrome: therapeutic 
      implications.
PG  - 313-6
AB  - Most forms of renal disease associated with monoclonal gammopathy result from 
      deposition of monoclonal immunoglobulins or their subunits in different 
      compartments of the kidney. Renal monoclonal immunoglobulin deposition disease 
      (MIDD) is defined by linear deposits of monoclonal light-chain components in 
      renal basement membranes, often producing a nodular sclerosing glomerulopathy. 
      Clinical features of renal MIDD include proteinuria, with or without renal 
      failure, and an association with dysproteinemias. Three types of renal MIDD have 
      been reported, namely, light-chain deposition disease (LCDD), light- and 
      heavy-chain deposition disease (LHCDD), and heavy-chain deposition disease 
      (HCDD). Reports on LHCDD are rare. At present, follow-up data are limited on the 
      management of renal monoclonal protein deposition disease. We present a case of 
      monoclonal protein deposition in the kidney containing both heavy and light 
      chains with unique characteristics that did not conform to any of the above 
      previous established classes. Its follow-up revealed an unusual relapsing and 
      remitting course in response to treatment.
FAU - Krishnan, Srivilliputtur G Santhana
AU  - Krishnan SG
AD  - Department of Medicine, Long Island Jewish Medical Center, New York, New York, 
      USA.
FAU - Valderrama, Elsa
AU  - Valderrama E
FAU - Wagner, John D
AU  - Wagner JD
FAU - Mattana, Joseph
AU  - Mattana J
FAU - Shah, Hitesh H
AU  - Shah HH
FAU - Appel, Gerald
AU  - Appel G
FAU - Singhal, Pravin C
AU  - Singhal PC
LA  - eng
GR  - SRO1DA12111/DA/NIDA NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Female
MH  - Glomerulonephritis, Membranoproliferative/immunology
MH  - Humans
MH  - Immunoglobulin Heavy Chains/immunology
MH  - Immunoglobulin Light Chains/immunology
MH  - Middle Aged
MH  - *Nephrotic Syndrome/diagnosis/immunology/pathology/therapy
MH  - *Paraproteinemias/diagnosis/immunology/pathology/therapy
MH  - Renal Insufficiency
EDAT- 2007/05/17 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/05/17 09:00
PHST- 2007/05/17 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/05/17 09:00 [entrez]
AID - S0002-9629(15)32577-5 [pii]
AID - 10.1097/MAJ.0b013e318053ce83 [doi]
PST - ppublish
SO  - Am J Med Sci. 2007 May;333(5):313-6. doi: 10.1097/MAJ.0b013e318053ce83.