PMID- 17505499 OWN - NLM STAT- MEDLINE DCOM- 20080410 LR - 20220309 IS - 1473-1150 (Electronic) IS - 1470-269X (Linking) VI - 8 IP - 2 DP - 2008 Apr TI - A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders. PG - 101-12 AB - Brain-derived neurotrophic factor (BDNF) has been studied extensively in relation to the susceptibility to mood disorders (MD), although it remains to be clarified whether BDNF is a susceptibility locus for MD phenotypes, including therapeutic response to antidepressants. We have performed a single-marker and haplotype association study of eight TagSNPs polymorphisms in the genomic region containing the BDNF gene in 342 control subjects and 374 patients with MD, and have tested the association with antidepressant treatment outcome. None of the eight single nucleotide polymorphisms (TagSNPs) was significantly associated with MD phenotype after Bonferroni correction. In the single-marker analysis, a SNP was found to be associated with the patient's state of 'remitter' after adequate trial with a single antidepressant phenotype (odds ratio (OR)=2.95; P=0.0025). We also identified a haplotype associated with this phenotype. This study supports the implication of BDNF in antidepressant treatment outcome in MD, with specific association with 5' upstream region of BDNF gene. FAU - Gratacos, M AU - Gratacos M AD - Genes and Disease Program, and CeGen Barcelona Genotyping Node, Center for Genomic Regulation (CRG), Barcelona, Spain. FAU - Soria, V AU - Soria V FAU - Urretavizcaya, M AU - Urretavizcaya M FAU - Gonzalez, J R AU - Gonzalez JR FAU - Crespo, J M AU - Crespo JM FAU - Bayes, M AU - Bayes M FAU - de Cid, R AU - de Cid R FAU - Menchon, J M AU - Menchon JM FAU - Vallejo, J AU - Vallejo J FAU - Estivill, X AU - Estivill X LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20070515 PL - United States TA - Pharmacogenomics J JT - The pharmacogenomics journal JID - 101083949 RN - 0 (5' Untranslated Regions) RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - 5' Untranslated Regions MH - Adult MH - Aged MH - Antidepressive Agents/*therapeutic use MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - Depressive Disorder, Major/drug therapy/genetics MH - Female MH - Gene Frequency MH - Genetic Predisposition to Disease MH - *Haplotypes MH - Humans MH - Male MH - Middle Aged MH - Mood Disorders/*drug therapy/genetics MH - Odds Ratio MH - Phenotype MH - *Polymorphism, Single Nucleotide MH - Risk Factors MH - Spain MH - Treatment Outcome EDAT- 2007/05/17 09:00 MHDA- 2008/04/11 09:00 CRDT- 2007/05/17 09:00 PHST- 2007/05/17 09:00 [pubmed] PHST- 2008/04/11 09:00 [medline] PHST- 2007/05/17 09:00 [entrez] AID - 6500460 [pii] AID - 10.1038/sj.tpj.6500460 [doi] PST - ppublish SO - Pharmacogenomics J. 2008 Apr;8(2):101-12. doi: 10.1038/sj.tpj.6500460. Epub 2007 May 15.