PMID- 17508918
OWN - NLM
STAT- MEDLINE
DCOM- 20070911
LR  - 20071203
IS  - 1523-0864 (Print)
IS  - 1523-0864 (Linking)
VI  - 9
IP  - 7
DP  - 2007 Jul
TI  - Cardiac synchronous and dys-synchronous remodeling in diabetes mellitus.
PG  - 971-8
AB  - Glucose-mediated impairment of homocysteine (Hcy) metabolism and decrease in 
      renal clearance contribute to hyperhomocysteinemia (HHcy) in diabetes. The Hcy 
      induces oxidative stress, inversely relates to the expression of peroxisome 
      proliferators activated receptor (PPAR), and contributes to diabetic 
      complications. Extracellular matrix (ECM) functionally links the endothelium to 
      the myocyte and is important for cardiac synchronization. However, in diabetes 
      and hyperhomocysteinemia, a "disconnection" is caused by activated matrix 
      metalloproteinase with subsequent accumulation of oxidized matrix (fibrosis) 
      between the endothelium and myocyte (E-M). This contributes to 
      "endothelial-myocyte uncoupling," attenuation of cardiac synchrony, leading to 
      diastolic heart failure (DHF), and cardiac dys-synchronizatrion. The decreased 
      levels of thioredoxin and peroxiredoxin and cardiac tissue inhibitor of 
      metalloproteinase are in response to antagonizing PPARgamma.
FAU - Sen, Utpal
AU  - Sen U
AD  - Department of Physiology and Biophysics, University of Louisville School of 
      Medicine, Louisville, KY 40202, USA.
FAU - Tyagi, Neetu
AU  - Tyagi N
FAU - Moshal, Karni S
AU  - Moshal KS
FAU - Kartha, Ganesh K
AU  - Kartha GK
FAU - Rosenberger, Dorothea
AU  - Rosenberger D
FAU - Henderson, Brooke C
AU  - Henderson BC
FAU - Joshua, Irving G
AU  - Joshua IG
FAU - Tyagi, Suresh C
AU  - Tyagi SC
LA  - eng
GR  - HL71010/HL/NHLBI NIH HHS/United States
GR  - HL74185/HL/NHLBI NIH HHS/United States
GR  - HL88012/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Antioxid Redox Signal
JT  - Antioxidants & redox signaling
JID - 100888899
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
SB  - IM
MH  - Animals
MH  - Cardiomyopathies/complications/metabolism/*physiopathology
MH  - Diabetic Angiopathies/complications/metabolism/*physiopathology
MH  - Endothelium, Vascular/metabolism/pathology/physiopathology
MH  - Humans
MH  - Hyperhomocysteinemia/complications/metabolism/*physiopathology
MH  - Models, Biological
MH  - *Oxidative Stress
MH  - Peroxisome Proliferator-Activated Receptors/metabolism
RF  - 125
EDAT- 2007/05/19 09:00
MHDA- 2007/09/12 09:00
CRDT- 2007/05/19 09:00
PHST- 2007/05/19 09:00 [pubmed]
PHST- 2007/09/12 09:00 [medline]
PHST- 2007/05/19 09:00 [entrez]
AID - 10.1089/ars.2007.1597 [doi]
PST - ppublish
SO  - Antioxid Redox Signal. 2007 Jul;9(7):971-8. doi: 10.1089/ars.2007.1597.