PMID- 17509084
OWN - NLM
STAT- MEDLINE
DCOM- 20070817
LR  - 20191210
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 25
IP  - 10
DP  - 2007 May
TI  - 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and 
      aversive effects of cocaine.
PG  - 3125-31
AB  - Whether serotonin-1B (5-HT(1B)) receptor activation enhances or diminishes the 
      reinforcing properties of psychostimulants remains unclear. We have previously 
      shown that increased expression of 5-HT(1B) receptors in nucleus accumbens (NAcc) 
      shell neurons sensitized rats to the locomotor-stimulating and rewarding 
      properties of cocaine. In this study we further examined the contribution of 
      5-HT(1B) receptors on the effect of cocaine under conditions intended to 
      selectively influence either conditioned place preference or avoidance (CPP or 
      CPA, respectively). Viral-mediated gene transfer techniques were used to 
      overexpress 5-HT(1B) receptors in medial NAcc shell medium spiny neurons 
      projecting to the ventral tegmental area. Animals were then conditioned to 
      associate place cues with the effects of either a low (5 mg/kg) or moderately 
      high (20 mg/kg) dosage of cocaine immediately or 45 min after intraperitoneal 
      cocaine administration. Animals with increased 5-HT(1B) expression showed 
      cocaine-induced CPP immediately after administration of the low 5 mg/kg dose of 
      cocaine, but a CPA 45 min after administration of the high 20 mg/kg dose. Control 
      animals showed no preference at the 5 mg/kg dose and a significant preference at 
      20 mg/kg. Given this, we believe that increased 5-HT(1B) receptor activation in 
      NAcc shell projection neurons intensifies both the rewarding and negative 
      properties of cocaine use.
FAU - Barot, Sabiha K
AU  - Barot SK
AD  - Program of Neurobiology and Behavior, Department of Psychology, Box 351525, 
      University of Washington, Seattle, WA 98195, USA.
FAU - Ferguson, Susan M
AU  - Ferguson SM
FAU - Neumaier, John F
AU  - Neumaier JF
LA  - eng
GR  - R01 DA016432/DA/NIDA NIH HHS/United States
GR  - R01 DA016432-04/DA/NIDA NIH HHS/United States
GR  - DA16432/DA/NIDA NIH HHS/United States
GR  - DA210090/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070517
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Receptor, Serotonin, 5-HT1B)
RN  - 333DO1RDJY (Serotonin)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects/physiology
MH  - Cocaine/*adverse effects
MH  - Cocaine-Related Disorders/*metabolism/physiopathology
MH  - Conditioning, Psychological/drug effects/physiology
MH  - Dopamine Uptake Inhibitors/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Genetic Vectors
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Neurons/drug effects/metabolism
MH  - Nucleus Accumbens/*drug effects/*metabolism/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1B/drug effects/genetics/*metabolism
MH  - *Reward
MH  - Serotonin/metabolism
MH  - Synaptic Transmission/drug effects/physiology
MH  - Transfection
EDAT- 2007/05/19 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/05/19 09:00
PHST- 2007/05/19 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/05/19 09:00 [entrez]
AID - EJN5568 [pii]
AID - 10.1111/j.1460-9568.2007.05568.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2007 May;25(10):3125-31. doi: 10.1111/j.1460-9568.2007.05568.x. 
      Epub 2007 May 17.