PMID- 17509453
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20111117
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 6
DP  - 2007 Jun
TI  - HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents 
      of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue 
      virus infection.
PG  - 531-40
AB  - Dengue virus infection has emerged as one of the most important arthropod-borne 
      diseases. In some dengue-infected individual, the disease progresses to its 
      severe, life-threatening form, dengue hemorrhagic fever (DHF). Host genetic 
      factors may be relevant and predispose some individuals to the severe dengue 
      disease. The unique history of dengue outbreaks in Cuba is extremely advantageous 
      for genetic studies of dengue disease resistance or susceptibility. Consequently, 
      samples collected from 120 healthy individuals that developed dengue fever (DF) 
      and DHF during the 1997 dengue 2 outbreak in the Santiago de Cuba municipality 
      were HLA genotyped using polymerase chain reaction-sequence-specific primers. 
      Polymorphism at the human leukocyte antigen (HLA) class I loci was significantly 
      associated with DHF disease susceptibility, but polymorphism in the HLA-DRB1 was 
      associated with protection. Amino acid peptides present in the poly-protein of 
      the dengue 2 Jamaica strain, which are able to bind to the HLA class I and class 
      II allotypes associated with susceptibility to or protection against the dengue 
      clinical disease, respectively, were predicted using the BIMAS and SYFPEITHI 
      predictive algorithms of peptide/MHC interaction.
FAU - Sierra, Beatriz
AU  - Sierra B
AD  - Institute of Tropical Medicine Pedro Kouri, WHO Collaborator Centre for Viral 
      Diseases, Havana, Cuba. siebet@ipk.sld.cu
FAU - Alegre, Roberto
AU  - Alegre R
FAU - Perez, Ana B
AU  - Perez AB
FAU - Garcia, Gissel
AU  - Garcia G
FAU - Sturn-Ramirez, Katharina
AU  - Sturn-Ramirez K
FAU - Obasanjo, Olugbenga
AU  - Obasanjo O
FAU - Aguirre, Eglys
AU  - Aguirre E
FAU - Alvarez, Mayling
AU  - Alvarez M
FAU - Rodriguez-Roche, Rosmari
AU  - Rodriguez-Roche R
FAU - Valdes, Luis
AU  - Valdes L
FAU - Kanki, Phyllis
AU  - Kanki P
FAU - Guzman, Maria G
AU  - Guzman MG
LA  - eng
PT  - Journal Article
DEP - 20070328
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Cuba/epidemiology
MH  - Dengue/epidemiology/genetics
MH  - Dengue Virus/*immunology
MH  - Female
MH  - *Gene Frequency
MH  - HLA-A Antigens/*genetics/immunology
MH  - HLA-B Antigens/*genetics/immunology
MH  - HLA-C Antigens/*genetics/immunology
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2007/05/19 09:00
MHDA- 2007/09/27 09:00
CRDT- 2007/05/19 09:00
PHST- 2006/11/15 00:00 [received]
PHST- 2007/02/02 00:00 [revised]
PHST- 2007/03/01 00:00 [accepted]
PHST- 2007/05/19 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/05/19 09:00 [entrez]
AID - S0198-8859(07)00050-X [pii]
AID - 10.1016/j.humimm.2007.03.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 Jun;68(6):531-40. doi: 10.1016/j.humimm.2007.03.001. Epub 2007 
      Mar 28.