PMID- 17509465
OWN - NLM
STAT- MEDLINE
DCOM- 20070808
LR  - 20070518
IS  - 0887-8994 (Print)
IS  - 0887-8994 (Linking)
VI  - 36
IP  - 5
DP  - 2007 May
TI  - Brain-derived neurotrophic factor rescues neurons from bacterial meningitis.
PG  - 324-9
AB  - Mortality and neurologic deficits still occurs frequently following bacterial 
      meningitis in children, despite antibiotic treatment. We investigated the 
      neuroprotective effects of brain-derived neurotrophic factor (BDNF) on brain 
      neurons in bacterial meningitis. The rat model of bacterial meningitis and a 
      normal rat model were developed. Either BDNF or albumin was injected into the 
      cerebral ventricle 24 hours after and before inoculation for 7 days, 
      respectively. Three of the rats treated with albumin died during the course of 
      treatment, but none of those treated with BDNF. The neuronal population in both 
      cerebral cortex and hippocampus of the rats treated with BDNF markedly increased, 
      compared with the rats treated with albumin, but there was no significant 
      difference between the rats treated with BDNF after and before inoculation, nor 
      between the normal rats treated with BDNF and albumin. The present findings 
      indicate that BDNF could protect a large number of neurons in cerebral cortex and 
      hippocampus from inflammatory brain injury in bacterial meningitis. The 
      administration of exogenous BDNF may be a new and effective way to decrease 
      mortality and improve sequelae following bacterial meningitis.
FAU - Li, Ling
AU  - Li L
AD  - Department of Pediatrics, First Affiliated Hospital of Kunming Medical College, 
      Kunming, China. hxyd_zjdx@hotmail.com
FAU - Shui, Quan-Xiang
AU  - Shui QX
FAU - Liang, Kun
AU  - Liang K
FAU - Ren, Hui
AU  - Ren H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Neurol
JT  - Pediatric neurology
JID - 8508183
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain Diseases/microbiology/pathology/*prevention & control
MH  - Brain-Derived Neurotrophic Factor/*therapeutic use
MH  - Cell Count
MH  - Cerebral Cortex/pathology
MH  - Disease Models, Animal
MH  - Hippocampus/pathology
MH  - Meningitis, Pneumococcal/*complications
MH  - Neurons
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2007/05/19 09:00
MHDA- 2007/08/09 09:00
CRDT- 2007/05/19 09:00
PHST- 2006/03/16 00:00 [received]
PHST- 2006/05/04 00:00 [revised]
PHST- 2007/01/08 00:00 [accepted]
PHST- 2007/05/19 09:00 [pubmed]
PHST- 2007/08/09 09:00 [medline]
PHST- 2007/05/19 09:00 [entrez]
AID - S0887-8994(07)00042-2 [pii]
AID - 10.1016/j.pediatrneurol.2007.01.007 [doi]
PST - ppublish
SO  - Pediatr Neurol. 2007 May;36(5):324-9. doi: 10.1016/j.pediatrneurol.2007.01.007.