PMID- 17510456
OWN - NLM
STAT- MEDLINE
DCOM- 20070801
LR  - 20161124
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 38
IP  - 7
DP  - 2007 Jul
TI  - Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor 
      recovery and stimulates neurogenesis.
PG  - 2165-72
AB  - BACKGROUND AND PURPOSE: The discovery of spontaneous neuronal replacement in the 
      adult brain has shifted experimental stroke therapies toward a combined approach 
      of preventing neuronal cell death and inducing neuronal plasticity. Brain-derived 
      neurotrophic factor (BDNF) was shown to induce antiapoptotic mechanisms after 
      stroke and to reduce infarct size and secondary neuronal cell death. Moreover, in 
      intact animals, BDNF is a potent stimulator of adult neurogenesis. METHODS: The 
      current study analyzed the effects of BDNF on induction of neuronal progenitor 
      cell migration and sensorimotor recovery after cortical photothrombotic stroke. 
      RESULTS: Daily intravenous bolus applications of BDNF during the first 5 days 
      after stroke resulted in significantly improved sensorimotor scores up to 6 
      weeks. At the structural level, BDNF significantly increased neurogenesis in the 
      dentate gyrus and enhanced migration of subventricular zone progenitor cells to 
      the nearby striatum of the ischemic hemisphere. BDNF treatment could not, 
      however, further stimulate progenitor cell recruitment to the cortex. 
      CONCLUSIONS: These findings consolidate the role of BDNF as a modulator of 
      neurogenesis in the brain and as an enhancer of long-term functional neurological 
      outcome after cerebral ischemia.
FAU - Schabitz, Wolf-Rudiger
AU  - Schabitz WR
AD  - Department of Neurology, University of Munster, Germany. schabitz@uni-muenster.de
FAU - Steigleder, Tobias
AU  - Steigleder T
FAU - Cooper-Kuhn, Christiana M
AU  - Cooper-Kuhn CM
FAU - Schwab, Stefan
AU  - Schwab S
FAU - Sommer, Clemens
AU  - Sommer C
FAU - Schneider, Armin
AU  - Schneider A
FAU - Kuhn, H Georg
AU  - Kuhn HG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070517
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
CIN - Stroke. 2009 Jul;40(7):e495; author reply e496. PMID: 19498194
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain/anatomy & histology/drug effects/pathology/physiology
MH  - Brain Ischemia/*drug therapy/pathology/rehabilitation
MH  - Brain-Derived Neurotrophic Factor/administration & 
      dosage/*pharmacology/*therapeutic use
MH  - Cell Differentiation/drug effects
MH  - Cell Movement/drug effects
MH  - Male
MH  - *Neurons/drug effects/physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - *Recovery of Function
MH  - Stem Cells/drug effects
MH  - Stroke/*drug therapy/pathology
MH  - Stroke Rehabilitation
MH  - Treatment Outcome
EDAT- 2007/05/19 09:00
MHDA- 2007/08/02 09:00
CRDT- 2007/05/19 09:00
PHST- 2007/05/19 09:00 [pubmed]
PHST- 2007/08/02 09:00 [medline]
PHST- 2007/05/19 09:00 [entrez]
AID - STROKEAHA.106.477331 [pii]
AID - 10.1161/STROKEAHA.106.477331 [doi]
PST - ppublish
SO  - Stroke. 2007 Jul;38(7):2165-72. doi: 10.1161/STROKEAHA.106.477331. Epub 2007 May 
      17.