PMID- 17510948
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20220318
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 144B
IP  - 8
DP  - 2007 Dec 5
TI  - The Val66Met polymorphism of the brain-derived neurotrophic factor gene is 
      associated with psychotic feature and suicidal behavior in Japanese major 
      depressive patients.
PG  - 1003-6
AB  - Recent researches have suggested that brain-derived neurotrophic factor (BDNF) 
      may be implicated in the pathophysiology of mood disorder. This study examined 
      the association between the BDNF Val66Met polymorphism and major depressive 
      disorder (MDD) in a Japanese population. We genotyped the BDNF Val66Met 
      polymorphism in 154 major depressive patients and 154 age- and sex-matched 
      control subjects. The genotypic distributions and allele frequencies were similar 
      among the patients and control subjects. When the relationships of the 
      polymorphism with several clinical variables (i.e., age, sex, age of onset, 
      number of episode, presence of psychotic features, suicidal behavior, and family 
      history) were examined, the dose of Met allele had significant effects on 
      psychotic feature and suicidal behavior and family history. These results suggest 
      that the BDNF Val66Met polymorphism is not related to the development of MDD but 
      related to clinical features of MDD in a Japanese population.
CI  - 2007 Wiley-Liss, Inc.
FAU - Iga, Jun-ichi
AU  - Iga J
AD  - Department of Psychiatry, Course of Integrated Brain Sciences, Medical 
      Informatics, Institute of Health Biosciences, The University of Tokushima 
      Graduate School, Tokushima, Japan.
FAU - Ueno, Shu-ichi
AU  - Ueno S
FAU - Yamauchi, Ken
AU  - Yamauchi K
FAU - Numata, Shusuke
AU  - Numata S
FAU - Tayoshi-Shibuya, Sumiko
AU  - Tayoshi-Shibuya S
FAU - Kinouchi, Sawako
AU  - Kinouchi S
FAU - Nakataki, Masahito
AU  - Nakataki M
FAU - Song, Hongwei
AU  - Song H
FAU - Hokoishi, Kazuhiko
AU  - Hokoishi K
FAU - Tanabe, Hirotaka
AU  - Tanabe H
FAU - Sano, Akira
AU  - Sano A
FAU - Ohmori, Tetsuro
AU  - Ohmori T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Age of Onset
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/complications/*genetics/psychology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Psychotic Disorders/*genetics/psychology
MH  - Sex Distribution
MH  - *Suicide
MH  - Valine/genetics
EDAT- 2007/05/19 09:00
MHDA- 2008/02/06 09:00
CRDT- 2007/05/19 09:00
PHST- 2007/05/19 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/05/19 09:00 [entrez]
AID - 10.1002/ajmg.b.30520 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):1003-6. doi: 
      10.1002/ajmg.b.30520.