PMID- 17511271
OWN - NLM
STAT- MEDLINE
DCOM- 20070622
LR  - 20070521
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 55
IP  - 4
DP  - 2007 Apr
TI  - [New diagnostic and evaluative tests for rheumatoid arthritis].
PG  - 388-96
AB  - To prevent joint destruction, it is important to diagnose RA early and to 
      consider the prognosis. For this purpose, several new laboratory tests, such as 
      IgG-RF, anti-agalactosyl IgG antibodies (CARF), and matrix metalloproteinase-3 
      (MMP-3), have become available for diagnosing RA. RF has a tolerable sensitivity 
      of 68.5% for RA, but low specificity of 77.1%, and also 76.0% for patients with 
      other rheumatic diseases and chronic inflammatory disease, respectively. CARF 
      showed slightly higher sensitivity but low specificity for other rheumatic 
      diseases and chronic inflammatory patients. In contrast, anti-cyclic 
      citrullinated peptide antibody (anti-CCP), a new diagnostic test for RA, 
      demonstrated significantly high specificity for other rheumatic diseases, and 
      also for chronic inflammatory disease patients. Anti-CCP was superior to other 
      laboratory tests by ROC analysis. Moreover, both CARF and anti-CCP had higher 
      sensitivity of 66.7%, 61.5%, respectively, for the diagnosis of early RA than RF. 
      On the other hand, MMP-3 is thought to be not only an evaluative test for the 
      activity of RA because of its significant correlation with CRP, but also has 
      potential as a prognostic test to identify joint damage from RA. Anti-CCP was 
      also reported to associate with the progression of joint damage and may be also 
      used as a prognostic test. We next examined the efficiency of RA diagnosis made 
      by combining these laboratory tests. The specificity of RF was not as high as 
      anti-CCP but reached 92% when combined with MMP-3. Thus, it is concluded that 
      anti-CCP is superior to other laboratory tests in sensitivity and specificity, 
      and that these combination assays are useful in the early diagnosis of RA.
FAU - Hayashi, Nobuhide
AU  - Hayashi N
AD  - Department of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017.
FAU - Nishimura, Kunihiro
AU  - Nishimura K
FAU - Morinobu, Akio
AU  - Morinobu A
FAU - Kumagai, Shunichi
AU  - Kumagai S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (agalactosyl IGG)
RN  - 0 (cyclic citrullinated peptide)
RN  - 9009-79-4 (Rheumatoid Factor)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Arthritis, Rheumatoid/*diagnosis
MH  - Autoantibodies/*blood
MH  - Humans
MH  - Immunoglobulin G/*immunology
MH  - Matrix Metalloproteinase 3/*blood
MH  - Peptides, Cyclic/*immunology
MH  - Rheumatoid Factor/*blood
MH  - Sensitivity and Specificity
RF  - 30
EDAT- 2007/05/22 09:00
MHDA- 2007/06/23 09:00
CRDT- 2007/05/22 09:00
PHST- 2007/05/22 09:00 [pubmed]
PHST- 2007/06/23 09:00 [medline]
PHST- 2007/05/22 09:00 [entrez]
PST - ppublish
SO  - Rinsho Byori. 2007 Apr;55(4):388-96.