PMID- 17511350
OWN - NLM
STAT- MEDLINE
DCOM- 20070605
LR  - 20071115
IS  - 0021-2938 (Print)
IS  - 0021-2938 (Linking)
VI  - 56
IP  - 1
DP  - 2007 Mar
TI  - Plasma levels of adrenomedullin and atrial natriuretic peptide in patients with 
      congestive heart failure of various etiologies.
PG  - 18-27
AB  - OBJECTIVE: The aim of this study was to evaluate the plasma levels of the 
      adrenomedullin (ADM) and atrial natriuretic peptide (ANP) in adult and pediatric 
      patients with congestive heart failure (CHF) of various etiologies and to 
      investigate their relations with haemodynamic variables e.g. echocardiographic 
      left ventricular ejection fraction (LVEF) and fractional shortening (FS). 
      SUBJECTS AND METHODS: The study was made in 38 adult and 21 pediatric patients 
      with CHF of various etiologies and compared with 15 adult and 10 pediatric normal 
      healthy controls. Patients with CHF were classified according to the New York 
      Heart Association (NYHA) functional classification into grades II to IV in adult 
      patients and into grade IV in all pediatric patients. ADM and ANP plasma levels 
      were determined prior to the treatment with enzyme immunoassay. RESULTS: A 
      statistically significant difference in the plasma levels of ADM and ANP were 
      found between pediatrics and adult patients and corresponding healthy controls. 
      Their levels were progressively increased with severity of NYHA class in adult 
      patients. We found a significant positive correlation between plasma levels of 
      each of ADM and ANP and pulse rate, systolic and diastolic blood pressure; and a 
      significant negative correlation between their plasma levels and 
      echocardiographic LVEF and FS. A significant positive correlation between plasma 
      levels of ADM and ANP in both pediatrics and adult patients were also found. 
      CONCLUSION: Plasma levels of ADM and ANP increased in adult and pediatric 
      patients with CHF irrespective of the cause. They were positively correlated with 
      each other and negatively correlated with LVEF and FS. These findings might have 
      important clinical implications in that a noninvasive blood test may be used to 
      identify high-risk subjects for HF for more invasive procedures.
FAU - Randa Abdel Kader, M
AU  - Randa Abdel Kader M
AD  - Medical Biochemistry Department, Faculty of Medicine, Cairo University. 
      randa592003@yahoo.co.uk
FAU - Grace, B D M
AU  - Grace BD
FAU - Badawi, N E S
AU  - Badawi NE
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Ital J Biochem
JT  - The Italian journal of biochemistry
JID - 0376564
RN  - 148498-78-6 (Adrenomedullin)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Adrenomedullin/*blood
MH  - Adult
MH  - Aged
MH  - Atrial Natriuretic Factor/*blood
MH  - Blood Pressure
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Heart Failure/*blood/etiology/physiopathology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Pulse
MH  - Ventricular Dysfunction, Left/complications
MH  - Ventricular Function, Left/physiology
EDAT- 2007/05/22 09:00
MHDA- 2007/06/06 09:00
CRDT- 2007/05/22 09:00
PHST- 2007/05/22 09:00 [pubmed]
PHST- 2007/06/06 09:00 [medline]
PHST- 2007/05/22 09:00 [entrez]
PST - ppublish
SO  - Ital J Biochem. 2007 Mar;56(1):18-27.