PMID- 17512153
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20070522
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 42
IP  - 7
DP  - 2007 Jul
TI  - Effect of a caloric restriction regimen on the angiogenic capacity of aorta and 
      on the expression of endothelin-1 during ageing.
PG  - 662-7
AB  - Ageing is accompanied by impaired angiogenesis, as well as by a deficient 
      expression of several angiogenic growth factors and the alteration of endothelial 
      functions. Caloric restriction (CR) is the only intervention that can extend 
      lifespan and retard age-related-decline functions in mammals by reducing the rate 
      of ageing and the progression of the associated diseases. Herein, we have 
      investigated the effects of ageing and of a caloric restriction regimen (mild or 
      severe) on the angiogenic response and on the expression of endothelin-1 (ET-1) 
      in the aorta of male 3-, 12- or 24-month-old Sprague-Dawley rats fed ad libitum 
      (AL), fed ad libitum and fasted 1 day a week (mild CR) or fasted every other in 
      alternate days (severe CR). Our findings, using the rat aorta ring assay, show 
      that the angiogenic capacity of aorta decreases with ageing in the oldest rats 
      only. Furthermore, caloric restriction counteracts the age-related changes 
      caloric restrictions actually give raise to a similar recovery. Interestingly, 
      the mRNA ET-1 levels as well as ET-1 expression in aorta sprouting decreases both 
      in middle and in aged animals. Mild and severe caloric restriction regimens 
      prevents ET-1 changes.
FAU - Facchetti, Floriana
AU  - Facchetti F
AD  - Department of Biomolecular Science and Biotechnology, University of Milan, Italy.
FAU - Monzani, Elena
AU  - Monzani E
FAU - Cavallini, Gabriella
AU  - Cavallini G
FAU - Bergamini, Ettore
AU  - Bergamini E
FAU - La Porta, Caterina A M
AU  - La Porta CA
LA  - eng
PT  - Journal Article
DEP - 20070412
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Aorta/growth & development/*physiology
MH  - *Diet, Reducing
MH  - Endothelium, Vascular/growth & development/*physiology
MH  - Fasting
MH  - Male
MH  - Neovascularization, Physiologic/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2007/05/22 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/05/22 09:00
PHST- 2006/11/15 00:00 [received]
PHST- 2007/03/16 00:00 [revised]
PHST- 2007/04/03 00:00 [accepted]
PHST- 2007/05/22 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/05/22 09:00 [entrez]
AID - S0531-5565(07)00081-2 [pii]
AID - 10.1016/j.exger.2007.04.001 [doi]
PST - ppublish
SO  - Exp Gerontol. 2007 Jul;42(7):662-7. doi: 10.1016/j.exger.2007.04.001. Epub 2007 
      Apr 12.