PMID- 17512913
OWN - NLM
STAT- MEDLINE
DCOM- 20070813
LR  - 20081121
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1155
DP  - 2007 Jun 25
TI  - Brain-derived neurotrophic factor-immunoreactive neurons in the rat vagal and 
      glossopharyngeal sensory ganglia; co-expression with other neurochemical 
      substances.
PG  - 93-9
AB  - Immunohistochemistry for brain-derived neurotrophic factor (BDNF) was performed 
      on the rat vagal and glossopharyngeal sensory ganglia. In the jugular, petrosal 
      and nodose ganglia, 56.1+/-5.5%, 52.4+/-9.4% and 80.0+/-3.0% of sensory neurons, 
      respectively, were immunoreactive for BDNF. These neurons were small- to 
      medium-sized and observed throughout the ganglia. In the solitary tract nucleus, 
      the neuropil showed BDNF immunoreactivity. A double immunofluorescence method 
      demonstrated that BDNF-immunoreactive neurons were also immunoreactive for 
      calcitonin gene-related peptide (CGRP), P2X3 receptor, the capsaicin receptor 
      (VR1) or vanilloid receptor 1-like receptor (VRL-1) in the jugular (CGRP, 43.5%; 
      P2X3 receptor, 51.1%; VR1, 71.7%; VRL-1, 0.5%), petrosal (CGRP, 33.2%; P2X3 
      receptor, 58.4%; VR1, 54.2%; VRL-1, 23.3%) and nodose ganglia (CGRP, 1.8%; P2X3 
      receptor, 49.1%; VR1, 70.7%; VRL-1, 11.5%). The co-expression with tyrosine 
      hydroxylase was also detected in the petrosal (2.9%) and nodose ganglia (2.2%). 
      However, BDNF-immunoreactive neurons were devoid of parvalbumin in these ganglia. 
      The present findings suggest that BDNF-containing vagal and glossopharyngeal 
      sensory neurons have nociceptive and chemoreceptive functions.
FAU - Ichikawa, H
AU  - Ichikawa H
AD  - Department of Oral Function and Anatomy, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. 
      hiroichi@md.okayama-u.ac.jp
FAU - Terayama, R
AU  - Terayama R
FAU - Yamaai, T
AU  - Yamaai T
FAU - Yan, Z
AU  - Yan Z
FAU - Sugimoto, T
AU  - Sugimoto T
LA  - eng
PT  - Journal Article
DEP - 20070521
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Aortic Bodies/cytology/*physiology
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Chemoreceptor Cells/physiology
MH  - Ganglia, Sensory/cytology/*physiology
MH  - Glomus Jugulare/cytology/physiology
MH  - Glossopharyngeal Nerve/*physiology
MH  - Models, Animal
MH  - Neurons/*physiology
MH  - Neurons, Afferent/physiology
MH  - Nodose Ganglion/cytology/physiology
MH  - Rats
EDAT- 2007/05/22 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/05/22 09:00
PHST- 2006/06/12 00:00 [received]
PHST- 2006/11/08 00:00 [revised]
PHST- 2006/11/08 00:00 [accepted]
PHST- 2007/05/22 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/05/22 09:00 [entrez]
AID - S0006-8993(06)03315-4 [pii]
AID - 10.1016/j.brainres.2006.11.024 [doi]
PST - ppublish
SO  - Brain Res. 2007 Jun 25;1155:93-9. doi: 10.1016/j.brainres.2006.11.024. Epub 2007 
      May 21.